{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:27:37Z","timestamp":1790501257887,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A set of coordinated interactions between gut microbiota and the immune cells surveilling the intestine play a key role in shaping local immune responses and intestinal health. Gpr109a is a G protein\u2013coupled receptor expressed at a very high level on innate immune cells and previously shown to play a key role in the induction of colonic regulatory T cells. In this study, we show that Gpr109a\u2212\/\u2212Rag1\u2212\/\u2212 mice exhibit spontaneous rectal prolapse and colonic inflammation, characterized by the presence of an elevated number of IL-17\u2013producing Ror\u03b3t+ innate lymphoid cells (ILCs; ILC3). Genetic deletion of Ror\u03b3t alleviated the spontaneous colonic inflammation in Gpr109a\u2212\/\u2212Rag1\u2212\/\u2212 mice. Gpr109a-deficient colonic dendritic cells produce higher amounts of IL-23 and thereby promote ILC3. Moreover, the depletion of gut microbiota by antibiotics treatment decreased IL-23 production, ILC3, and colonic inflammation in Gpr109a\u2212\/\u2212Rag1\u2212\/\u2212 mice. The ceca of Gpr109a\u2212\/\u2212Rag1\u2212\/\u2212 mice showed significantly increased colonization by members of Bacteroidaceae, Porphyromonadaceae, Prevotellaceae, Streptococcaceae, Christensenellaceae, and Mogibacteriaceae, as well as IBD-associated microbiota such as Enterobacteriaceae and Mycoplasmataceae, compared with Rag1\u2212\/\u2212 mice, housed in a facility positive for Helicobacter and murine norovirus. Niacin, a Gpr109a agonist, suppressed both IL-23 production by colonic DCs and ILC3 number in a Gpr109a-dependent manner. Collectively, our data present a model suggesting that targeting Gpr109a will be potentially beneficial in the suppression of IL-23\u2013mediated immunopathologies.<\/jats:p>","DOI":"10.4049\/jimmunol.1701625","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T17:51:16Z","timestamp":1520445076000},"page":"2905-2914","source":"Crossref","is-referenced-by-count":72,"title":["Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation"],"prefix":"10.1093","volume":"200","author":[{"given":"Brinda","family":"Bhatt","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish","family":"Sivaprakasam","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center , Lubbock, TX 79430"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-6818","authenticated-orcid":false,"given":"Siyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Georgia Institute of Technology , Atlanta, GA 30332"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Nursing, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-4844","authenticated-orcid":false,"given":"Lixin","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Nursing, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-8372","authenticated-orcid":false,"given":"Pamela","family":"Shiao","sequence":"additional","affiliation":[{"name":"College of Nursing, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8283-2403","authenticated-orcid":false,"given":"Ravindra","family":"Kolhe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-0082","authenticated-orcid":false,"given":"Nikhil","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3604-0982","authenticated-orcid":false,"given":"Honglin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Augusta University , Augusta, GA 30912"},{"name":"Georgia Cancer Center, Augusta University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Levy-Bercowski","sequence":"additional","affiliation":[{"name":"Dental College of Georgia, Augusta University , Augusta, GA 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