{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:20:53Z","timestamp":1770088853818,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD8+ T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in circulating CD8+ T cells, to determine the protective capacity of class Ib MHC-restricted T cells during L. monocytogenes infection. The Kb\u2212\/\u2212Db\u2212\/\u2212 mutation was backcrossed onto a C.B10 (BALB\/c congenic at H-2 locus with C57BL\/10) background, because BALB\/c mice are more susceptible to Listeria infection than other commonly studied mouse strains such as C57BL\/6. C.B10 Kb\u2212\/\u2212Db\u2212\/\u2212 mice immunized with a sublethal dose of L. monocytogenes were fully protected against a subsequent lethal infection. Adoptive transfer of Listeria-immune splenocyte subsets into naive Kb\u2212\/\u2212Db\u2212\/\u2212 mice indicated that CD8+ T cells were the major component of this protective immune response. A CD8+ T cell line isolated from the spleen of a Listeria-infected class Ia MHC-deficient mouse was shown to specifically recognize Listeria-infected cells in vitro, as determined by IFN-\u03b3 secretion and cytotoxicity assays. Adoptive transfer of this T cell line alone resulted in significant protection against L. monocytogenes challenge. These results suggest that even a limited number of class Ib MHC-restricted T cells are sufficient to generate the rapid recall response required for protection against secondary infection with L. monocytogenes.<\/jats:p>","DOI":"10.4049\/jimmunol.171.1.291","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:28:08Z","timestamp":1398022088000},"page":"291-298","source":"Crossref","is-referenced-by-count":27,"title":["Class Ia MHC-Deficient BALB\/c Mice Generate CD8+ T Cell-Mediated Protective Immunity Against\n                    <i>Listeria monocytogenes<\/i>\n                    Infection"],"prefix":"10.1093","volume":"171","author":[{"given":"Sarah E F","family":"D\u2019Orazio","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina G","family":"Halme","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidde L","family":"Ploegh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N","family":"Starnbach","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,7,1]]},"reference":[{"key":"2026020210160152100_R1","first-page":"1597","volume-title":"J. 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