{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:02:14Z","timestamp":1790413334607,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We determined whether the absence of IL-10 in mice influenced protective and memory immunity to Histoplasma capsulatum. IL-10\u2212\/\u2212 mice cleared primary and secondary infection more rapidly than wild-type controls. Administration of mAb to TNF-\u03b1 or IFN-\u03b3, but not GM-CSF, abrogated protection in naive IL-10\u2212\/\u2212 mice; mAb toTNF-\u03b1, but not IFN-\u03b3 or GM-CSF, subverted protective immunity in secondary histoplasmosis. The inflammatory cell composition in IL-10\u2212\/\u2212 mice was altered in those given mAb to IFN-\u03b3 or TNF-\u03b1. More Gr-1+ and Mac-3+ cells were present in lungs of IL-10\u2212\/\u2212 mice given mAb to IFN-\u03b3, and treatment with mAb to TNF-\u03b1 sharply reduced the number of CD8+ cells in lungs of IL-10\u2212\/\u2212 mice. We ascertained whether the lack of IL-10 modulated memory T cell generation or the protective function of cells. The percentage of CD3+, CD44high, CD62low, and IFN-\u03b3+ cells in IL-10\u2212\/\u2212 mice was higher than that of wild-type at day 7 but not day 21 or 49 after immunization. Fewer splenocytes from immunized IL-10\u2212\/\u2212 mice were required to mediate protection upon adoptive transfer into infected TCR \u03b1\u03b2\u2212\/\u2212 mice. Hence, deficiency of IL-10 confers a salutary effect on the course of histoplasmosis, and the beneficial effects of IL-10 deficiency require endogenous TNF-\u03b1 and\/or IFN-\u03b3. Memory cell generation was transiently increased in IL-10\u2212\/\u2212 mice, but the protective function conferred by cells from these mice following immunization is strikingly more vigorous than that of wild-type.<\/jats:p>","DOI":"10.4049\/jimmunol.171.10.5353","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:22:42Z","timestamp":1398018162000},"page":"5353-5362","source":"Crossref","is-referenced-by-count":33,"title":["Protective and Memory Immunity to\n                    <i>Histoplasma capsulatum<\/i>\n                    in the Absence of IL-10"],"prefix":"10.1093","volume":"171","author":[{"suffix":"Jr.","given":"George S","family":"Deepe","sequence":"first","affiliation":[{"name":"Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reta S","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,11,15]]},"reference":[{"key":"2026020211105505100_R1","first-page":"2718","volume-title":"Principles and Practice of Infectious Diseases","year":"2000"},{"key":"2026020211105505100_R2","first-page":"785","volume-title":"J. 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