{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:10:05Z","timestamp":1792188605855,"version":"4.4.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aging is associated with reduced trapping of Ag in the form of in immune complexes (ICs) by follicular dendritic cells (FDCs). We postulated that this defect was due to altered regulation of IC trapping receptors. The level of FDC-M1, complement receptors 1 and 2, Fc\u03b3RII, and FDC-M2 on FDCs was immunohistochemically quantitated in draining lymph nodes of actively immunized mice for 10 days after Ag challenge. Initially, FDC Fc\u03b3RII levels were similar but by day 3 a drastic reduction in FDC-Fc\u03b3RII expression was apparent in old mice. FDC-M2 labeling, reflecting IC trapping, was also reduced and correlated with a dramatic reduction in germinal center (GC) B cells as indicated by reduced GC size and number. Nevertheless, labeling of FDC reticula with FDC-M1 and anti-complement receptors 1 and 2 was preserved, indicating that FDCs were present. FDCs in active GCs normally express high levels of FcRs that are thought to bind Fc portions of Abs in ICs and minimize their binding to FcRs on B cells. Thus, cross-linking of B cell receptor and FcR via IC is minimized, thereby reducing signaling via the immunoreceptor tyrosine-based inhibition motif. Old FDCs taken at day 3, when they lack Fc\u03b3RII, were incapable of preventing immunoreceptor tyrosine-based inhibition motif signaling in wild-type B cells but old FDCs stimulated B cells from Fc\u03b3RIIB\u2212\/\u2212 mice to produce near normal levels of specific Ab. The present data support the concept that FcR are regulated abnormally on old FDCs. This abnormality correlates with a reduced IC retention and with a reduced capacity of FDCs to present ICs in a way that will activate GC B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.171.11.5975","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:01Z","timestamp":1398029521000},"page":"5975-5987","source":"Crossref","is-referenced-by-count":61,"title":["Altered Regulation of Fc\u03b3RII on Aged Follicular Dendritic Cells Correlates with Immunoreceptor Tyrosine-Based Inhibition Motif Signaling in B Cells and Reduced Germinal Center Formation"],"prefix":"10.1093","volume":"171","author":[{"given":"Yu\u0308ksel","family":"Aydar","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology, The Immunology Group, Virginia Commonwealth University, Medical College of Virginia , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pe\u0301ter","family":"Balogh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, The Immunology Group, Virginia Commonwealth University, Medical College of Virginia , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Tew","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Medical College of Virginia , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras K","family":"Szakal","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, The Immunology Group, Virginia Commonwealth University, Medical College of Virginia , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"2026020211094945300_R1","first-page":"75","volume-title":"Exp. 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