{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:33:06Z","timestamp":1770089586051,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antineutrophil cytoplasmic Abs (ANCA) can activate neutrophils in an Fc\u03b3R-dependent manner, but the link between this ANCA-induced effect and mononuclear cell activation with the characteristic granuloma formation of Wegener\u2019s granulomatosis is unclear. Human \u03b1-defensins, small cationic antimicrobial peptides, are found in neutrophils and have chemotactic activity for T cells, dendritic cells, and monocytes. In this study, we quantitated the release of \u03b1-defensins (human neutrophil peptides 1\u20133) from human neutrophils after targeted Fc\u03b3R cross-linking (XL). Homotypic XL of Fc\u03b3RIIa, Fc\u03b3RIIIb, or heterotypic XL of both receptors resulted in significant release of \u03b1-defensins, an effect also induced by both human polyclonal and murine monoclonal cytoplasmic staining ANCA (anti-proteinase 3). This release of \u03b1-defensins, as well as of other granule constituents (ANCA targets anti-proteinase 3 and myeloperoxidase and elastase), was significantly greater in donors homozygous for the NA1 allele of Fc\u03b3RIIIb than in donors homozygous for NA2. Interestingly, the ANCA-induced release was completely inhibited by the IgG Fc-binding peptide TG19320, which blocks the IgG-Fc region from binding to Fc\u03b3R. Based on their chemotactic properties, \u03b1-defensins and their release by ANCA may contribute to modulation of the acquired immune response and to granuloma formation. The greater activity of the Fc\u03b3RIIIB-NA1 genotype may also explain the greater severity of disease and its flare-ups in patients with this allele.<\/jats:p>","DOI":"10.4049\/jimmunol.171.11.6090","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:01Z","timestamp":1398029521000},"page":"6090-6096","source":"Crossref","is-referenced-by-count":21,"title":["Fc\u03b3RIIIb Allele-Sensitive Release of \u03b1-Defensins: Anti-Neutrophil Cytoplasmic Antibody-Induced Release of Chemotaxins"],"prefix":"10.1093","volume":"171","author":[{"given":"Sumiaki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C","family":"Edberg","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama , Birmingham, AL 35294"},{"name":"Department of Microbiology, University of Alabama , Birmingham, AL 35294"},{"name":"XEPTAGEN SpA , Pozzuoli ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winn","family":"Chatham","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Fassina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P","family":"Kimberly","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama , Birmingham, AL 35294"},{"name":"Department of Microbiology, University of Alabama , Birmingham, AL 35294"},{"name":"XEPTAGEN SpA , Pozzuoli ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"2026020210232207700_R1","first-page":"3503","volume-title":"Blood","year":"1997"},{"key":"2026020210232207700_R2","first-page":"201","volume-title":"J. 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