{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T04:58:03Z","timestamp":1770094683498,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>NK cell self-tolerance is maintained by inhibitory receptors specific for MHC class I molecules. Inhibitory NK receptors are also expressed on memory CD8 T cells but their biological relevance on T cells is unclear. In this study, we describe the expression of the Ly49A receptor on a subset of autoreactive T cells which persist in mice double-transgenic for the lymphocytic choriomeningitis virus-derived peptide gp33 and a TCR\u03b1\u03b2 specific for the gp33. No Ly49A-expressing cells are found in TCR\u03b1\u03b2 single-transgenic mice, indicating that the presence of the autoantigen is required for Ly49A induction. Direct evidence for an Ag-specific initiation of Ly49A expression has been obtained in vitro after stimulation of autoreactive TCR\u03b1\u03b2 T cells with the cognate self-Ag. This expression of Ly49A substantially reduces Ag-specific activation of autoreactive T cells. These findings thus suggest that autoantigen-specific induction of inhibitory NK cell receptors on T cells may contribute to peripheral self-tolerance.<\/jats:p>","DOI":"10.4049\/jimmunol.171.12.6334","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:30:32Z","timestamp":1398029432000},"page":"6334-6338","source":"Crossref","is-referenced-by-count":5,"title":["Cutting Edge: Stimulation with the Cognate Self-Antigen Induces Expression of the Ly49A Receptor on Self-Reactive T Cells Which Modulates Their Responsiveness"],"prefix":"10.1093","volume":"171","author":[{"given":"Leslie","family":"Saurer","sequence":"first","affiliation":[{"name":"Institute of Pathology, Division of Immunopathology, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Seibold","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Division of Immunopathology, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Vallan","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Division of Immunopathology, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Held","sequence":"additional","affiliation":[{"name":"Ludwig Institute of Cancer Research, University of Lausanne , Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Mueller","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Division of Immunopathology, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,12,15]]},"reference":[{"key":"2026020210235959000_R1","first-page":"67","volume-title":"Immunol. 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