{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:56:54Z","timestamp":1791014214330,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dendritic cells (DCs) appear to be strategically implicated in allergic diseases, including asthma. Matrix metalloproteinase (MMP)-9 mediates transmigration of inflammatory leukocytes across basement membranes. This study investigated the role of MMP-9 in airway DC trafficking during allergen-induced airway inflammation. MMP-9 gene deletion affected the trafficking of pulmonary DCs in a specific way: only the inflammatory transmigration of DCs into the airway lumen was impaired, whereas DC-mediated transport of airway Ag to the thoracic lymph nodes remained unaffected. In parallel, the local production of the Th2-attracting chemokine CC chemokine ligand 17\/thymus and activation-regulated chemokine, which was highly concentrated in purified lung DCs, fell short in the airways of allergen-exposed MMP-9\u2212\/\u2212 mice. This was accompanied by markedly reduced peribronchial eosinophilic infiltrates and impaired allergen-specific IgE production. We conclude that the specific absence of MMP-9 activity inhibits the development of allergic airway inflammation by impairing the recruitment of DCs into the airways and the local production of DC-derived proallergic chemokines.<\/jats:p>","DOI":"10.4049\/jimmunol.171.2.1016","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:29:26Z","timestamp":1398022166000},"page":"1016-1022","source":"Crossref","is-referenced-by-count":117,"title":["Matrix Metalloproteinase-9-Mediated Dendritic Cell Recruitment into the Airways Is a Critical Step in a Mouse Model of Asthma"],"prefix":"10.1093","volume":"171","author":[{"given":"Karim Y","family":"Vermaelen","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases, Ghent University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Cataldo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University of Lie\u0300ge , Lie\u0300ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Tournoy","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Ghent University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Maes","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Ghent University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Dhulst","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Ghent University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University of Lie\u0300ge , Lie\u0300ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Foidart","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of Tumors and Development, University of Lie\u0300ge , Lie\u0300ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agne\u0300s","family":"Noe\u0308l","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of Tumors and Development, University of Lie\u0300ge , Lie\u0300ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Ghent University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,7,15]]},"reference":[{"key":"2026020210240616500_R1","first-page":"245","volume-title":"Nature","year":"1998"},{"key":"2026020210240616500_R2","first-page":"51","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026020210240616500_R3","first-page":"551","volume-title":"J. Clin. Invest.","year":"2000"},{"key":"2026020210240616500_R4","first-page":"4090","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020210240616500_R5","first-page":"10","volume-title":"Respir. Res.","year":"2001"},{"key":"2026020210240616500_R6","first-page":"21491","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2026020210240616500_R7","first-page":"161","volume-title":"Nat. Rev. Cancer","year":"2002"},{"key":"2026020210240616500_R8","first-page":"1160","volume-title":"Blood","year":"2002"},{"key":"2026020210240616500_R9","first-page":"851","volume-title":"J. Leukocyte Biol.","year":"2001"},{"key":"2026020210240616500_R10","first-page":"259","volume-title":"Int. Arch. Allergy Immunol.","year":"2000"},{"key":"2026020210240616500_R11","first-page":"590","volume-title":"Thorax","year":"1999"},{"key":"2026020210240616500_R12","first-page":"217","volume-title":"Clin. Exp. Allergy","year":"2002"},{"key":"2026020210240616500_R13","first-page":"212","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"1997"},{"key":"2026020210240616500_R14","first-page":"145","volume-title":"Allergy","year":"2001"},{"key":"2026020210240616500_R15","first-page":"39","volume-title":"Lab. Invest.","year":"1999"},{"key":"2026020210240616500_R16","first-page":"4212","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210240616500_R17","first-page":"1021","volume-title":"J. Allergy Clin. Immunol.","year":"2001"},{"key":"2026020210240616500_R18","first-page":"491","volume-title":"Am. J. Pathol.","year":"2002"},{"key":"2026020210240616500_R19","first-page":"411","volume-title":"Cell","year":"1998"},{"key":"2026020210240616500_R20","first-page":"77","volume-title":"J. Immunol. Methods","year":"1999"},{"key":"2026020210240616500_R21","first-page":"2472","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020210240616500_R22","first-page":"228","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210240616500_R23","first-page":"157","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020210240616500_R24","first-page":"825","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020210240616500_R25","first-page":"2472","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210240616500_R26","first-page":"673","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2026020210240616500_R27","first-page":"206","volume-title":"Clin. Exp. Allergy","year":"2001"},{"key":"2026020210240616500_R28","first-page":"504","volume-title":"J. Leukocyte Biol.","year":"1993"},{"key":"2026020210240616500_R29","first-page":"3663","volume-title":"Blood","year":"2002"},{"key":"2026020210240616500_R30","first-page":"271","volume-title":"Immunity","year":"2002"},{"key":"2026020210240616500_R31","first-page":"5989","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210240616500_R32","first-page":"4361","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020210240616500_R33","first-page":"383","volume-title":"Eur. J. Cell Biol.","year":"2002"},{"key":"2026020210240616500_R34","first-page":"3942","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1996"},{"key":"2026020210240616500_R35","first-page":"361","volume-title":"Nat. Immunol.","year":"2001"},{"key":"2026020210240616500_R36","first-page":"581","volume-title":"J. Immunol.","year":"2003"},{"key":"2026020210240616500_R37","first-page":"2138","volume-title":"J. Immunol.","year":"2003"},{"key":"2026020210240616500_R38","first-page":"265","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020210240616500_R39","first-page":"5027","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020210240616500_R40","first-page":"403","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210240616500_R41","first-page":"81","volume-title":"Int. Immunol.","year":"1999"},{"key":"2026020210240616500_R42","first-page":"2055","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210240616500_R43","first-page":"2205","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020210240616500_R44","first-page":"1923","volume-title":"Clin. Exp. Allergy","year":"2001"},{"key":"2026020210240616500_R45","first-page":"382","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"2001"},{"key":"2026020210240616500_R46","first-page":"173","volume-title":"Allergy","year":"2002"},{"key":"2026020210240616500_R47","first-page":"2684","volume-title":"Eur. J. Immunol.","year":"1999"},{"key":"2026020210240616500_R48","first-page":"585","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026020210240616500_R49"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/171\/2\/1016\/62586052\/1016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/171\/2\/1016\/62586052\/1016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:32:18Z","timestamp":1770046338000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/171\/2\/1016\/8031223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,7,15]]},"published-print":{"date-parts":[[2003,7,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.171.2.1016","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,7]]},"published":{"date-parts":[[2003,7]]}}}