{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:36:46Z","timestamp":1770086206843,"version":"3.49.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A vaccine regimen that can rapidly control HIV-1 replication at the site of exposure following sexual contact is likely to be the most effective in preventing HIV-1 infection. As part of a larger, phase II clinical trial, we evaluated the ability of a recombinant canarypox HIV-1 vaccine to induce CTL that can be detected in both the systemic and mucosal compartments following i.m. immunization in 12 low- and high-risk HIV-1 seronegative volunteers. In the 7 volunteers receiving four immunizations with live recombinant canarypox ALVAC-HIV vaccine with or without rgp120\/SF-2, HIV-1-specific CTL were detected in the blood of 5 (71%) and in the rectum of 4 (57%). CTL responses were observed in both risk strata. In contrast, 5 volunteers receiving placebo had undetectable responses in both compartments. Vaccine-induced, HIV-1-specific effector activities included IFN-\u03b3 secretion and class I MHC-restricted CD8+ CTL. Rectal and systemic CD8+ CTL clones established in 1 vaccine recipient revealed similar Env-specific responses and MHC restriction. These findings indicate that parenteral vaccination can induce HIV-1-specific CTL that localize to sites of HIV-1 acquisition, where their presence may be critical in the control of initial viral replication and eventual dissemination. Determination of the optimal strategy to induce mucosal T cells requires future clinical studies.<\/jats:p>","DOI":"10.4049\/jimmunol.171.2.1094","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:29:26Z","timestamp":1398022166000},"page":"1094-1101","source":"Crossref","is-referenced-by-count":32,"title":["HIV-1 Vaccination Administered Intramuscularly Can Induce Both Systemic and Mucosal T Cell Immunity in HIV-1-Uninfected Individuals"],"prefix":"10.1093","volume":"171","author":[{"given":"Luwy","family":"Musey","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[{"name":"Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, WA 98109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnie","family":"Elizaga","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"},{"name":"Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, WA 98109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ha","sequence":"additional","affiliation":[{"name":"Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, WA 98109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie","family":"Celum","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Juliana","family":"McElrath","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA 98195"},{"name":"Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, WA 98109"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,7,15]]},"reference":[{"key":"2026020210173576500_R1","first-page":"226","volume-title":"The Report on the Global HIV\/AIDS Epidemic 2002","year":"2002"},{"key":"2026020210173576500_R2","first-page":"4650","volume-title":"J. Virol.","year":"1994"},{"key":"2026020210173576500_R3","first-page":"6103","volume-title":"J. Virol.","year":"1994"},{"key":"2026020210173576500_R4","first-page":"1267","volume-title":"N. Engl. J. Med.","year":"1997"},{"key":"2026020210173576500_R5","first-page":"1317","volume-title":"J. Infect. Dis.","year":"1998"},{"key":"2026020210173576500_R6","first-page":"486","volume-title":"Science","year":"2000"},{"key":"2026020210173576500_R7","first-page":"59","volume-title":"Nat. Med.","year":"1995"},{"key":"2026020210173576500_R8","first-page":"1250","volume-title":"Nat. Med.","year":"1997"},{"key":"2026020210173576500_R9","first-page":"548","volume-title":"J. Infect. Dis.","year":"1999"},{"key":"2026020210173576500_R10","first-page":"5855","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020210173576500_R11","first-page":"4508","volume-title":"J. Virol.","year":"1999"},{"key":"2026020210173576500_R12","first-page":"293","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020210173576500_R13","first-page":"4406","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020210173576500_R14","first-page":"1602","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020210173576500_R15","first-page":"767","volume-title":"Nat. Med.","year":"1996"},{"key":"2026020210173576500_R16","first-page":"4981","volume-title":"J. Virol.","year":"1997"},{"key":"2026020210173576500_R17","first-page":"34","volume-title":"J. Med. Primatol.","year":"1997"},{"key":"2026020210173576500_R18","first-page":"225","volume-title":"Dev. Biol. Stand.","year":"1998"},{"key":"2026020210173576500_R19","first-page":"540","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210173576500_R20","first-page":"2072","volume-title":"J. Clin. Invest.","year":"1998"},{"key":"2026020210173576500_R21","first-page":"291","volume-title":"J. Virol.","year":"2003"},{"key":"2026020210173576500_R22","first-page":"633","volume-title":"AIDS Res. Hum. Retroviruses","year":"1999"},{"key":"2026020210173576500_R23","first-page":"563","volume-title":"J. Infect. Dis.","year":"2001"},{"key":"2026020210173576500_R24","first-page":"1343","volume-title":"J. Infect. Dis.","year":"2001"},{"key":"2026020210173576500_R25","first-page":"2306","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210173576500_R26","first-page":"859","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020210173576500_R27","first-page":"S35","volume-title":"AIDS","year":"1998"},{"key":"2026020210173576500_R28","first-page":"3066","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026020210173576500_R29","first-page":"11484","volume-title":"J. Virol.","year":"2002"},{"key":"2026020210173576500_R30","first-page":"183","volume-title":"Immunol. Lett.","year":"1999"},{"key":"2026020210173576500_R31","first-page":"189","volume-title":"Immunol. Lett.","year":"1999"},{"key":"2026020210173576500_R32","first-page":"207","volume-title":"Nat. Med.","year":"2000"},{"key":"2026020210173576500_R33","first-page":"2261","volume-title":"AIDS","year":"1998"},{"key":"2026020210173576500_R34","first-page":"252","volume-title":"Virology","year":"1999"},{"key":"2026020210173576500_R35","first-page":"363","volume-title":"Microbiol. Immunol.","year":"2000"},{"key":"2026020210173576500_R36","first-page":"8638","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2026020210173576500_R37","first-page":"1858","volume-title":"J. Immunol.","year":"1994"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/171\/2\/1094\/62585586\/1094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/171\/2\/1094\/62585586\/1094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:23:06Z","timestamp":1770045786000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/171\/2\/1094\/8030748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,7,15]]},"published-print":{"date-parts":[[2003,7,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.171.2.1094","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,7]]},"published":{"date-parts":[[2003,7]]}}}