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We therefore questioned how well virus Ag-specific memory CD8+ T cells could reconstitute mice rendered lymphopenic as a consequence of genetics, irradiation, or viral or poly(I:C)-induced cytokines. In each case, reconstitution of the CD8+ compartment was associated with limited division of virus-specific memory T cells and a reduction in their proportion. This indicates that foreign Ag-experienced CD44highCD8+ memory T cells may respond differently to homeostatic signals than other CD44highCD8+ cells, and that events inducing lymphopenia may lead to a permanent reduction in T cell memory.<\/jats:p>","DOI":"10.4049\/jimmunol.171.2.655","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:29:26Z","timestamp":1398022166000},"page":"655-663","source":"Crossref","is-referenced-by-count":33,"title":["Attrition of Virus-Specific Memory CD8+ T Cells During Reconstitution of Lymphopenic Environments"],"prefix":"10.1093","volume":"171","author":[{"given":"Craig D","family":"Peacock","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical Center , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Kwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical Center , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond M","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical Center , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,7,15]]},"reference":[{"key":"2026020210184961300_R1","first-page":"575","volume-title":"Immunol. 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