{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:52:58Z","timestamp":1793087578557,"version":"4.5.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The development of experimental Lyme arthritis has been correlated with the expression of a number of chemokines and cytokines, however, none of these have been measured directly from the arthritic joint. We examined the temporal expression of IL-1\u03b2, IL-4, IL-6, IL-10, IL-12p70, GM-CSF, IFN-\u03b3, TNF-\u03b1, macrophage inflammatory protein-2, KC, macrophage inflammatory protein-1\u03b1, and monocyte chemoattractant protein-1 directly from the tibiotarsal joint in arthritis-resistant C57BL\/6 (B6) and -susceptible C3H\/He (C3H) mice. Only the chemokines KC and monocyte chemoattractant protein-1 were differentially expressed in joints of B6 and C3H mice and correlated with the development of Lyme arthritis. Infection of CXCR2\u2212\/\u2212 mice on either genetic background resulted in a significant decrease in the development of pathology, although infection of CCR2\u2212\/\u2212 mice had little or no effect. Neutrophils in CXCR2\u2212\/\u2212 mice were marginalized within blood vessels and could not enter the joint tissue. These results suggest that chemokine-mediated recruitment of neutrophils into the infected joint is a key requirement for the development of experimental Lyme arthritis.<\/jats:p>","DOI":"10.4049\/jimmunol.171.2.893","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:29:26Z","timestamp":1398022166000},"page":"893-901","source":"Crossref","is-referenced-by-count":97,"title":["Susceptibility to Experimental Lyme Arthritis Correlates with KC and Monocyte Chemoattractant Protein-1 Production in Joints and Requires Neutrophil Recruitment Via CXCR2"],"prefix":"10.1093","volume":"171","author":[{"given":"Charles R","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri , Columbia, MO 65211"},{"name":"Department of Veterinary Pathobiology, University of Missouri , Columbia, MO 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria A","family":"Blaho","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Missouri , Columbia, MO 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M","family":"Loiacono","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, University of Missouri , Columbia, MO 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,7,15]]},"reference":[{"key":"2026020210180994700_R1","first-page":"29","volume-title":"Morbid. 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