{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:55:19Z","timestamp":1791291319038,"version":"4.3.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rapid removal of pathogens from the circulation by secondary lymphoid organs is prerequisite for successful control of infection. Blood-borne Ags are trapped mainly in the splenic marginal zone. To identify the cell populations responsible for Ag trapping in the marginal zone, mice were selectively depleted of marginal zone macrophages and marginal metallophilic macrophages. In the absence of these cells, trapping of microspheres and Listeria monocytogenes organisms was lost, and early control of infection was impaired. Depletion of marginal zone macrophages and marginal metallophilic macrophages, however, did not limit Ag presentation because Listeria-specific protective T cell immunity was induced. Therefore, marginal zone macrophages and marginal metallophilic macrophages are crucial for trapping of particulate Ag but dispensable for Ag presentation.<\/jats:p>","DOI":"10.4049\/jimmunol.171.3.1148","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:29:45Z","timestamp":1398029385000},"page":"1148-1155","source":"Crossref","is-referenced-by-count":198,"title":["Macrophages of the Splenic Marginal Zone Are Essential for Trapping of Blood-Borne Particulate Antigen but Dispensable for Induction of Specific T Cell Responses"],"prefix":"10.1093","volume":"171","author":[{"given":"Peter","family":"Aichele","sequence":"first","affiliation":[{"name":"Abteilung Immunologie, Max-Planck-Institut fu\u0308r Infektionsbiologie , Berlin ,","place":["Germany"]},{"name":"Institut fur Medizinische Mikrobiologie Hygiene, Universita\u0304tsklinikum Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Zinke","sequence":"additional","affiliation":[{"name":"Abteilung Immunologie, Max-Planck-Institut fu\u0308r Infektionsbiologie , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leander","family":"Grode","sequence":"additional","affiliation":[{"name":"Abteilung Immunologie, Max-Planck-Institut fu\u0308r Infektionsbiologie , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto A","family":"Schwendener","sequence":"additional","affiliation":[{"name":"Institut fur Medizinische Mikrobiologie Hygiene, Universita\u0304tsklinikum Freiburg , Freiburg ,","place":["Germany"]},{"name":"Paul Scherrer Institute , Villingen ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H E","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Abteilung Immunologie, Max-Planck-Institut fu\u0308r Infektionsbiologie , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Seiler","sequence":"additional","affiliation":[{"name":"Abteilung Immunologie, Max-Planck-Institut fu\u0308r Infektionsbiologie , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,8,1]]},"reference":[{"key":"2026020210185278600_R1","first-page":"31","volume-title":"Int. Rev. Cytol.","year":"1992"},{"key":"2026020210185278600_R2","first-page":"103","volume-title":"Adv. Drug Deliv. Rev.","year":"1995"},{"key":"2026020210185278600_R3","first-page":"23","volume-title":"Spleen, Structure, Function and Clinical Significance","year":"1990"},{"key":"2026020210185278600_R4","first-page":"23","volume-title":"Immunology","year":"1985"},{"key":"2026020210185278600_R5","first-page":"211","volume-title":"Eur. J. Immunol.","year":"1981"},{"key":"2026020210185278600_R6","first-page":"149","volume-title":"Anat. Rec.","year":"1964"},{"key":"2026020210185278600_R7","first-page":"665","volume-title":"Immunology","year":"1986"},{"key":"2026020210185278600_R8","first-page":"237","volume-title":"Virchows Arch","year":"1985"},{"key":"2026020210185278600_R9","first-page":"4220","volume-title":"Infect. Immun.","year":"1996"},{"key":"2026020210185278600_R10","first-page":"63","volume-title":"Immunobiology","year":"1991"},{"key":"2026020210185278600_R11","first-page":"675","volume-title":"Eur. J. Immunol.","year":"1989"},{"key":"2026020210185278600_R12","first-page":"719","volume-title":"Eur. J. Immunol.","year":"1992"},{"key":"2026020210185278600_R13","first-page":"37","volume-title":"Pharm. Res.","year":"1999"},{"key":"2026020210185278600_R14","first-page":"463","volume-title":"Pharm. Res.","year":"1997"},{"key":"2026020210185278600_R15","first-page":"263","volume-title":"Cell Tissue Res.","year":"1986"},{"key":"2026020210185278600_R16","first-page":"231","volume-title":"J. Immunol. Methods","year":"1992"},{"key":"2026020210185278600_R17","first-page":"466","volume-title":"Eur. J. Immunol.","year":"1995"},{"key":"2026020210185278600_R18","first-page":"13","volume-title":"Immunobiology","year":"1993"},{"key":"2026020210185278600_R19","first-page":"1972","volume-title":"Infect. Immun.","year":"1992"},{"key":"2026020210185278600_R20","first-page":"3386","volume-title":"J. Immunol.","year":"1994"},{"key":"2026020210185278600_R21","first-page":"355","volume-title":"Cell Tissue Res.","year":"1984"},{"key":"2026020210185278600_R22","first-page":"2626","volume-title":"Eur. J. Immunol.","year":"1997"},{"key":"2026020210185278600_R23","first-page":"83","volume-title":"J. Immunol. Methods","year":"1994"},{"key":"2026020210185278600_R24","first-page":"381","volume-title":"J. Exp. Med.","year":"1962"},{"key":"2026020210185278600_R25","first-page":"129","volume-title":"Annu. Rev. Immunol.","year":"1993"},{"key":"2026020210185278600_R26","first-page":"259","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2026020210185278600_R27","first-page":"5090","volume-title":"Infect. Immun.","year":"1993"},{"key":"2026020210185278600_R28","first-page":"5161","volume-title":"Infect. Immun.","year":"1994"},{"key":"2026020210185278600_R29","first-page":"5","volume-title":"Immunol. Rev.","year":"1991"},{"key":"2026020210185278600_R30","first-page":"35","volume-title":"Curr. Opin. Immunol.","year":"1997"},{"key":"2026020210185278600_R31","first-page":"249","volume-title":"Microb. Pathog.","year":"1986"},{"key":"2026020210185278600_R32","first-page":"105","volume-title":"J. Exp. Med.","year":"1964"},{"key":"2026020210185278600_R33","first-page":"295","volume-title":"J. Med. Microbiol.","year":"1996"},{"key":"2026020210185278600_R34","first-page":"763","volume-title":"Am. J. Pathol.","year":"1995"},{"key":"2026020210185278600_R35","first-page":"407","volume-title":"J. Electron Microsc.","year":"1996"},{"key":"2026020210185278600_R36","first-page":"579","volume-title":"J. Leukocyte Biol.","year":"1991"},{"key":"2026020210185278600_R37","first-page":"986","volume-title":"Infect. Immun.","year":"1997"},{"key":"2026020210185278600_R38","first-page":"391","volume-title":"Scand. J. Immunol.","year":"1999"},{"key":"2026020210185278600_R39","first-page":"355","volume-title":"Scand. J. Immunol.","year":"1996"},{"key":"2026020210185278600_R40","first-page":"507","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020210185278600_R41","first-page":"5","volume-title":"Immunol. Rev.","year":"1995"},{"key":"2026020210185278600_R42","first-page":"1451","volume-title":"Eur. J. Immunol.","year":"1990"},{"key":"2026020210185278600_R43","first-page":"1329","volume-title":"Life Sci.","year":"1999"},{"key":"2026020210185278600_R44","first-page":"2115","volume-title":"Infect. Immun.","year":"1994"},{"key":"2026020210185278600_R45","first-page":"11","volume-title":"Immunol. Today","year":"1992"},{"key":"2026020210185278600_R46","first-page":"4","volume-title":"Curr. Opin. Immunol.","year":"1997"},{"key":"2026020210185278600_R47","first-page":"20","volume-title":"Curr. Opin. Immunol.","year":"1996"},{"key":"2026020210185278600_R48","first-page":"2156","volume-title":"Science","year":"1999"},{"key":"2026020210185278600_R49","first-page":"545","volume-title":"Annu. Rev. Immunol.","year":"1998"},{"key":"2026020210185278600_R50","first-page":"69","volume-title":"Immunol. Rev.","year":"1997"},{"key":"2026020210185278600_R51","first-page":"11490","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1995"},{"key":"2026020210185278600_R52","first-page":"76","volume-title":"Curr. Opin. Immunol.","year":"1991"},{"key":"2026020210185278600_R53","first-page":"363","volume-title":"Semin. Immunol.","year":"1998"},{"key":"2026020210185278600_R54","first-page":"603","volume-title":"Cell","year":"1995"},{"key":"2026020210185278600_R55","first-page":"83","volume-title":"Arch. Histol. Cytol.","year":"1999"},{"key":"2026020210185278600_R56","first-page":"179","volume-title":"Am. J. Pathol.","year":"2001"},{"key":"2026020210185278600_R57","first-page":"147","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020210185278600_R58","first-page":"23","volume-title":"Int. Immunol.","year":"1996"},{"key":"2026020210185278600_R59","first-page":"2157","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020210185278600_R60","first-page":"669","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2026020210185278600_R61","first-page":"3136","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2026020210185278600_R62","first-page":"1175","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020210185278600_R63","first-page":"1909","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210185278600_R64","first-page":"479","volume-title":"Immunity","year":"1997"},{"key":"2026020210185278600_R65","first-page":"9302","volume-title":"Proc. Natl. Acad. Sci.","year":"1997"},{"key":"2026020210185278600_R66","first-page":"559","volume-title":"Am. J. Pathol.","year":"1996"},{"key":"2026020210185278600_R67","first-page":"1453","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020210185278600_R68","first-page":"1446","volume-title":"Eur. J. Immunol.","year":"1995"},{"key":"2026020210185278600_R69","first-page":"346","volume-title":"Res. Immunol.","year":"1991"},{"key":"2026020210185278600_R70","first-page":"617","volume-title":"Immunity","year":"2001"},{"key":"2026020210185278600_R71","first-page":"9","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2026020210185278600_R72","first-page":"7198","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210185278600_R73","first-page":"455","volume-title":"Immunology","year":"1998"},{"key":"2026020210185278600_R74","first-page":"679","volume-title":"Int. Immunol.","year":"1995"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/171\/3\/1148\/62586136\/1148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/171\/3\/1148\/62586136\/1148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:24:50Z","timestamp":1770045890000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/171\/3\/1148\/8030824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,1]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,8,1]]},"published-print":{"date-parts":[[2003,8,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.171.3.1148","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,8]]},"published":{"date-parts":[[2003,8,1]]}}}