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Ligation of CCR3 by eotaxin\/chemokine ligand (CCL) 11 induces apoptosis in IL-2- and IL-4-stimulated primary CD19+ (\u223c40% apoptotic cells) B cell cultures as well as B cell lines, but has no effect on chemotaxis or cell adhesion. Freshly isolated B cells express low levels of CD95 and CD95 ligand (CD95L) (19 and 21%, respectively). Expression is up-regulated on culture in the presence of a combination of IL-2, IL-4, and eotaxin\/CCL11 (88% CD95 and 84% CD95L). We therefore propose that ligation of such newly induced CCR3 on peripheral and germinal B cells by eotaxin\/CCL11 leads to the enhanced levels of CD95 and CD95L expression. Ligation of CD95 by its CD95L expressed on neigboring B cells triggers relevant death signaling pathways, which include an increase in levels of Bcl-2 expression, its functional activity, and the release of cytochrome c from the mitochondria into the cytosol. These events initiate a cascade of enzymatic processes of the caspase family, culminating in programmed cell death. Interaction between CCR3 and eotaxin\/CCL11 may, besides promoting allergic reactions, drive activated B cells to apoptosis, thereby reducing levels of Ig production, including IgE, and consequently limit the development of the humoral immune response. The apoptotic action of eotaxin\/CCL11 suggests a therapeutic modality in the treatment of B cell lymphoma.<\/jats:p>","DOI":"10.4049\/jimmunol.171.4.1722","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:42:39Z","timestamp":1398022959000},"page":"1722-1731","source":"Crossref","is-referenced-by-count":22,"title":["CCR3 Expression Induced by IL-2 and IL-4 Functioning as a Death Receptor for B Cells"],"prefix":"10.1093","volume":"171","author":[{"given":"Tan","family":"Jinquan","sequence":"first","affiliation":[{"name":"Biological Allergy Research , H\u00f8rsholm ,","place":["Denmark"]},{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik H","family":"Jacobi","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jing","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Millner","sequence":"additional","affiliation":[{"name":"Biological Allergy Research , H\u00f8rsholm ,","place":["Denmark"]},{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sten","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Center of Medical Parasitology, Department of Infectious Diseases, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Anting","sequence":"additional","affiliation":[{"name":"Biological Allergy Research , H\u00f8rsholm ,","place":["Denmark"]},{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars P","family":"Ryder","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Typing, Department of Clinical Immunology, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Glue","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per S","family":"Skov","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Jarman","sequence":"additional","affiliation":[{"name":"Biological Allergy Research , H\u00f8rsholm ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Lamberth","sequence":"additional","affiliation":[{"name":"Institute of Medical Anatomy, Panum Institute, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00f8rgen","family":"Malling","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars K","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Allergology, Allergy Clinic, National University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,8,15]]},"reference":[{"key":"2026020211065115100_R1","first-page":"593","volume-title":"Annu. 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