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In this study, we determine factors that regulate CTL localization and tumoricidal function after intracerebral implantation of tumors expressing model Ag. H-2bxd mice implanted with a CW3+ murine glioma lacking H-2Kd molecules necessary to present the CW3170\u2013179 epitope demonstrate cross-priming of H-2Kd-restricted CTL, and moreover, Ag-dependent accumulation of functional H-2Kd\/CW3170\u2013179-specific CTL within the tumor bed. This implicates a role for cross-presentation not only in priming, but also in retention of fully differentiated CTL in the tumor stroma at the effector stage of the response. Modulating cross-presentation of Ag may be the key in regulating specific immune responses in the brain: either by augmenting protective responses or by down-modulating destructive autoimmune reactions.<\/jats:p>","DOI":"10.4049\/jimmunol.171.5.2187","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:54:01Z","timestamp":1398027241000},"page":"2187-2191","source":"Crossref","is-referenced-by-count":51,"title":["Cutting Edge: Cross-Presentation as a Mechanism for Efficient Recruitment of Tumor-Specific CTL to the Brain"],"prefix":"10.1093","volume":"171","author":[{"given":"Thomas","family":"Calzascia","sequence":"first","affiliation":[{"name":"Laboratory of Tumour Immunology, Division of Oncology, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Di Berardino-Besson","sequence":"additional","affiliation":[{"name":"Laboratory of Tumour Immunology, Division of Oncology, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Wilmotte","sequence":"additional","affiliation":[{"name":"Laboratory of Tumour Immunology, Division of Oncology, University Hospital Geneva , Geneva ,","place":["Switzerland"]},{"name":"Department of Neurosurgery, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301rick","family":"Masson","sequence":"additional","affiliation":[{"name":"Laboratory of Tumour Immunology, Division of Oncology, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"de Tribolet","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Laboratory of Tumour Immunology, Division of Oncology, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Walker","sequence":"additional","affiliation":[{"name":"Laboratory of Tumour Immunology, Division of Oncology, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"2026020210172190600_R1","first-page":"218","volume-title":"Immunol. 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