{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:19:08Z","timestamp":1789885148200,"version":"4.0.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Identifying and characterizing Ag-specific CD8+ T cells are central to the study of immunological memory. Although powerful strategies such as MHC tetramers and peptide-induced cytokine production assays exist for identifying Ag-specific CD8+ T cells, alternate strategies that are not dependent upon a priori knowledge of the immunodominant and subdominant antigenic epitopes, as well as the MHC background of the animal are of obvious utility. In this study, we present a transgenic mouse model that uses Cre-loxP recombination to permanently mark all activated CD8+ T cells with \u03b2-galactosidase. We used the lymphocytic choriomeningitis virus infection model to track the dynamics of the antiviral CD8+ T cell responses. We show that in this transgenic mouse model system, all of the antiviral effector and memory CD8+ T cells are contained within the \u03b2-gal-marked CD8+ T cell population.<\/jats:p>","DOI":"10.4049\/jimmunol.171.5.2393","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:54:01Z","timestamp":1398027241000},"page":"2393-2401","source":"Crossref","is-referenced-by-count":18,"title":["A Transgenic Mouse Model Genetically Tags All Activated CD8 T Cells"],"prefix":"10.1093","volume":"171","author":[{"given":"Charles H","family":"Maris","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Altman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshy","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"2026020210172446100_R1","first-page":"79","volume-title":"Immunol. 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