{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:43:24Z","timestamp":1791287004237,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, thereby partially mimicking human disease. Using this model, we have demonstrated that mice deficient in \u03b3\u03b4 T cells are more susceptible to WN virus infection. TCR\u03b4\u2212\/\u2212 mice have elevated viral loads and greater dissemination of the pathogen to the CNS. In wild-type mice, \u03b3\u03b4 T cells expanded significantly during WN virus infection, produced IFN-\u03b3 in ex vivo assays, and enhanced perforin expression by splenic T cells. Adoptive transfer of \u03b3\u03b4 T cells to TCR\u03b4\u2212\/\u2212 mice reduced the susceptibility of these mice to WN virus, and this effect was primarily due to IFN-\u03b3-producing \u03b3\u03b4 T cells. These data demonstrate a distinct role for \u03b3\u03b4 T cells in the control of and prevention of mortality from murine WN virus infection.<\/jats:p>","DOI":"10.4049\/jimmunol.171.5.2524","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:54:01Z","timestamp":1398027241000},"page":"2524-2531","source":"Crossref","is-referenced-by-count":153,"title":["IFN-\u03b3-Producing \u03b3\u03b4 T Cells Help Control Murine West Nile Virus Infection"],"prefix":"10.1093","volume":"171","author":[{"given":"Tian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Scully","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520"},{"name":"Section of Immunobiology, Yale University , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mamula","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Entomology, Connecticut Agricultural Experiment Station , New Haven, CT 06504"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Craft","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520"},{"name":"Section of Immunobiology, Yale University , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"2026020210175082300_R1","first-page":"2331","volume-title":"Science","year":"1999"},{"key":"2026020210175082300_R2","first-page":"2333","volume-title":"Science","year":"1999"},{"key":"2026020210175082300_R3","first-page":"223","volume-title":"Curr. 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