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Viable streptococci were predominantly found both intra- and extracellularly in nasal-associated lymphoid tissue (NALT), a human tonsil homologue. Ulex europaeus-1, a membranous (M) cell-specific lectin, identified cells harboring streptococci at the epithelial surface of NALT and blocked bacterial colonization of this tissue. These results suggest that M cells in NALT transport this Gram-positive pathogen across the epithelial layers in a manner similar to those in Peyer\u2019s patches, which permit enteric pathogens to invade deeper tissues from the gastrointestinal tract.<\/jats:p>","DOI":"10.4049\/jimmunol.171.5.2532","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:54:01Z","timestamp":1398027241000},"page":"2532-2537","source":"Crossref","is-referenced-by-count":129,"title":["Membranous Cells in Nasal-Associated Lymphoid Tissue: A Portal of Entry for the Respiratory Mucosal Pathogen Group A Streptococcus"],"prefix":"10.1093","volume":"171","author":[{"given":"Hae-Sun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P","family":"Francis","sequence":"additional","affiliation":[{"name":"Xenogen Corp. , Alameda, CA 94501"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[{"name":"Xenogen Corp. , Alameda, CA 94501"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Patrick","family":"Cleary","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"2026020210192321300_R1","first-page":"27","volume-title":"Gram-Positive Pathogens","year":"2000"},{"key":"2026020210192321300_R2","first-page":"12115","volume-title":"Proc. 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