{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T04:02:54Z","timestamp":1770091374998,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although the anterior chamber of the eye expresses immune privilege, some ocular tumors succumb to immune rejection. Previous studies demonstrated that adenovirus-induced tumors, adenovirus type 5 early region 1 (Ad5E1), underwent immune rejection following transplantation into the anterior chamber of syngeneic mice. Intraocular tumor rejection required CD4+ T cells, but did not require the following: 1) CD8+ T cells, 2) B cells, 3) TNF, 4) perforin, 5) Fas ligand, or 6) NK cells. This study demonstrates that CD4+ T cell-dependent tumor rejection does not occur in IFN-\u03b3-deficient mice. Ad5E1 tumor cells expressed DR5 receptor for TRAIL and were susceptible to TRAIL-induced apoptosis. Although IFN-\u03b3 did not directly induce apoptosis of the tumor cells, it rendered them 3-fold more susceptible to TRAIL-induced apoptosis. Both CD4+ T cells and corneal endothelial cells expressed TRAIL and induced apoptosis of Ad5E1 tumor cells. The results suggest that Ad5E1 tumor rejection occurs via TRAIL-induced apoptosis as follows: 1) tumor cells express TRAIL-R2 and are susceptible to TRAIL-induced apoptosis, 2) IFN-\u03b3 enhances TRAIL expression on CD4+ T cells and ocular cells, 3) IFN-\u03b3 enhances tumor cell susceptibility to TRAIL-induced apoptosis, 4) apoptotic tumor cells are found in the eyes of rejector mice, but not in the eyes of IFN-\u03b3 knockout mice that fail to reject intraocular tumors, 5) CD4+ T cells and corneal endothelial cells express TRAIL and induce apoptosis of tumor cells, and 6) apoptosis induced by either CD4+ T cells or corneal cells can be blocked with anti-TRAIL Ab.<\/jats:p>","DOI":"10.4049\/jimmunol.171.6.2789","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:21:12Z","timestamp":1398018072000},"page":"2789-2796","source":"Crossref","is-referenced-by-count":41,"title":["Role of TRAIL and IFN-\u03b3 in CD4+ T Cell-Dependent Tumor Rejection in the Anterior Chamber of the Eye"],"prefix":"10.1093","volume":"171","author":[{"given":"Shixuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita F H M","family":"Boonman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Chuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuGuang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine J","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene E M","family":"Toes","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]},{"name":"Department of Rheumatology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry Y","family":"Niederkorn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,9,15]]},"reference":[{"key":"2026020210184976200_R1","first-page":"13","volume-title":"Crit. 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