{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:03:38Z","timestamp":1774566218545,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adhesive interactions are crucial to cell migration into inflammatory sites. Using murine lymphocytic choriomeningitis virus as an Ag model system, we have investigated expression and function of collagen-binding integrins, \u03b11\u03b21 and \u03b12\u03b21, on activated and memory T cells. Using this system and MHC tetramers to define Ag-specific T cells, we demonstrate that contrary to being VLAs, expression of \u03b11\u03b21 and \u03b12\u03b21 can be rapidly induced on acutely activated T cells, that expression of \u03b11\u03b21 remains elevated on memory T cells, and that expression of \u03b11\u03b21 parallels that of viral-specific effector CD8+ T cells (defined by tetramer and IFN-\u03b3 staining). In an adoptive transfer model, mAb-mediated blockade of these integrins on activated effector and memory T cells inhibited Ag-specific delayed-type hypersensitivity responses; similar decreased responses were seen upon transfer of \u03b11-deficient activated\/memory T cells. Thus, expression of \u03b11\u03b21 and \u03b12\u03b21 integrins on activated T cells is directly functionally important for generation of inflammatory responses within tissues. Finally, the inhibitory effect of \u03b11\u03b21 blockade on the delayed-type hypersensitivity response could be bypassed by direct injection of Ag-specific T cells to inflammatory sites, demonstrating for the first time in vivo that collagen-binding integrins are involved in leukocyte migration into tissues.<\/jats:p>","DOI":"10.4049\/jimmunol.171.6.2804","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:21:12Z","timestamp":1398018072000},"page":"2804-2811","source":"Crossref","is-referenced-by-count":34,"title":["Expression and Functional Importance of Collagen-Binding Integrins, \u03b11\u03b21 and \u03b12\u03b21, on Virus-Activated T Cells"],"prefix":"10.1093","volume":"171","author":[{"given":"Susanne \u00d8","family":"Andreasen","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Immunology, Panum Institute , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan R","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Immunology, Panum Institute , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor E","family":"Koteliansky","sequence":"additional","affiliation":[{"name":"Biogen , Cambridge, MA 02142"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana I","family":"Novobrantseva","sequence":"additional","affiliation":[{"name":"Biogen , Cambridge, MA 02142"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G","family":"Sprague","sequence":"additional","affiliation":[{"name":"Biogen , Cambridge, MA 02142"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin R","family":"de Fougerolles","sequence":"additional","affiliation":[{"name":"Biogen , Cambridge, MA 02142"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P","family":"Christensen","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Immunology, Panum Institute , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,9,15]]},"reference":[{"key":"2026020210234344100_R1","first-page":"301","volume-title":"Cell","year":"1994"},{"key":"2026020210234344100_R2","first-page":"721","volume-title":"J. 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