{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:51:03Z","timestamp":1790250663533,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The V\u03b34+ pulmonary subset of \u03b3\u03b4 T cells regulates innate airway responsiveness in the absence of \u03b1\u03b2 T cells. We now have examined the same subset in a model of allergic airway disease, OVA-sensitized and challenged mice that exhibit Th2 responses, pulmonary inflammation, and airway hyperreactivity (AHR). In sensitized mice, V\u03b34+ cells preferentially increased in number following airway challenge. Depletion of V\u03b34+ cells before the challenge substantially increased AHR in these mice, but had no effect on airway responsiveness in normal, nonchallenged mice. Depletion of V\u03b31+ cells had no effect on AHR, and depletion of all TCR-\u03b4+ cells was no more effective than depletion of V\u03b34+ cells alone. Adoptively transferred pulmonary lymphocytes containing V\u03b34+ cells inhibited AHR, but lost this ability when V\u03b34+ cells were depleted, indicating that these cells actively suppress AHR. Eosinophilic infiltration of the lung and airways, or goblet cell hyperplasia, was not affected by depletion of V\u03b34+ cells, although cytokine-producing \u03b1\u03b2 T cells in the lung increased. These findings establish V\u03b34+ \u03b3\u03b4 T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR.<\/jats:p>","DOI":"10.4049\/jimmunol.171.6.3170","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:21:12Z","timestamp":1398018072000},"page":"3170-3178","source":"Crossref","is-referenced-by-count":53,"title":["V\u03b34+ \u03b3\u03b4 T Cells Regulate Airway Hyperreactivity to Methacholine in Ovalbumin-Sensitized and Challenged Mice"],"prefix":"10.1093","volume":"171","author":[{"given":"Youn-Soo","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"},{"name":"Department of Pediatrics, Chungbuk National University and College of Medicine , Cheongju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Taube","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, Department of Pediatrics at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, Department of Pediatrics at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Won","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, Department of Pediatrics at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Wands","sequence":"additional","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Kemal","family":"Aydintug","sequence":"additional","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L","family":"Roark","sequence":"additional","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lahn","sequence":"additional","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin W","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, Department of Pediatrics at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi K","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Immunology at National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,9,15]]},"reference":[{"key":"2026020210225233500_R1","first-page":"255","volume-title":"Annu. 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