{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:49:50Z","timestamp":1794037790625,"version":"4.8.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We fit a mathematical model to data characterizing the primary cellular immune response to lymphocytic choriomeningitis virus. The data enumerate the specific CD8+ T cell response to six MHC class I-restricted epitopes and the specific CD4+ T cell responses to two MHC class II-restricted epitopes. The peak of the response occurs around day 8 for CD8+ T cells and around day 9 for CD4+ T cells. By fitting a model to the data, we characterize the kinetic differences between CD4+ and CD8+ T cell responses and among the immunodominant and subdominant responses to the various epitopes. CD8+ T cell responses have faster kinetics in almost every aspect of the response. For CD8+ and CD4+ T cells, the doubling time during the initial expansion phase is 8 and 11 h, respectively. The half-life during the contraction phase following the peak of the response is 41 h and 3 days, respectively. CD4+ responses are even slower because their contraction phase appears to be biphasic, approaching a 35-day half-life 8 days after the peak of the response. The half-life during the memory phase is 500 days for the CD4+ T cell responses and appears to be lifelong for the six CD8+ T cell responses. Comparing the responses between the various epitopes, we find that immunodominant responses have an earlier and\/or larger recruitment of precursors cells before the expansion phase and\/or have a faster proliferation rate during the expansion phase.<\/jats:p>","DOI":"10.4049\/jimmunol.171.8.3928","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:53:23Z","timestamp":1398027203000},"page":"3928-3935","source":"Crossref","is-referenced-by-count":243,"title":["Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection"],"prefix":"10.1093","volume":"171","author":[{"given":"Rob J","family":"De Boer","sequence":"first","affiliation":[{"name":"Theoretical Biology, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Homann","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Division of Virology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S","family":"Perelson","sequence":"additional","affiliation":[{"name":"Theoretical Division, Los Alamos National Laboratory , Los Alamos, NM 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,10,15]]},"reference":[{"key":"2026020210175654000_R1","first-page":"648","volume-title":"Nature","year":"1994"},{"key":"2026020210175654000_R2","first-page":"2165","volume-title":"J. 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