{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:05:20Z","timestamp":1772895920787,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mice expressing the X-linked immunodeficiency (xid) mutation lack functional Bruton\u2019s tyrosine kinase and were shown to be specifically deficient in peritoneal B-1 lymphocytes. We have previously shown that IL-9, a cytokine produced by TH2 lymphocytes, promotes B-1 cell expansion in vivo. To determine whether IL-9 overexpression might compensate the xid mutation for B-1 lymphocyte development, we crossed xid mice with IL-9-transgenic mice. In this model, IL-9 restored normal numbers of mature peritoneal B-1 cells that all belonged to the CD5\u2212 B-1b subset. Despite this normal B-1 lymphocyte number, IL-9 failed to restore classical functions of B-1 cells, namely, the production of natural IgM Abs, the T15 Id Ab response to phosphorylcholine immunization, and the antipolysaccharide humoral response against Streptococcus pneumoniae. By using bromelain-treated RBC, we showed that the antigenic repertoire of these IL-9-induced B-1b lymphocytes was different from the repertoire of classical CD5+ B-1a cells, indicating that the lack of B-1 function by B-1b cells is associated with distinct Ag specificities. Taken together, our data show that B-1b cell development can restore the peritoneal B-1 population in xid mice but that these B-1b cells are functionally distinct from CD5+ B-1a lymphocytes.<\/jats:p>","DOI":"10.4049\/jimmunol.172.10.6101","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:55:35Z","timestamp":1398027335000},"page":"6101-6106","source":"Crossref","is-referenced-by-count":29,"title":["IL-9-Induced Expansion of B-1b Cells Restores Numbers but Not Function of B-1 Lymphocytes in\n                    <i>xid<\/i>\n                    Mice"],"prefix":"10.1093","volume":"172","author":[{"given":"Laurent","family":"Knoops","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research and Experimental Medicine Unit, Universite\u0301 de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamila","family":"Louahed","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research and Experimental Medicine Unit, Universite\u0301 de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Renauld","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research and Experimental Medicine Unit, Universite\u0301 de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,5,15]]},"reference":[{"key":"2026020211281000700_R1","first-page":"202","volume-title":"J. 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