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In an attempt of such a quantification, we directly compared the amount of exogenous virus-like particles required for induction of cytotoxic T cell responses by cross-priming with the amount of virus-like particles required for induction of Th cell responses by the conventional route of MHC class II loading as an internal standard. Surprisingly, we found that cross-presentation of peptides derived from exogenous Ags on MHC class I molecules is of only marginally lower efficiency (\u223c1- to 10-fold) than the classical MHC class II pathway in vitro and in vivo. Thus, Ag quantities required for cross-presentation and cross-priming are similar to those required for fueling the MHC class II pathway.<\/jats:p>","DOI":"10.4049\/jimmunol.172.10.6129","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:55:35Z","timestamp":1398027335000},"page":"6129-6135","source":"Crossref","is-referenced-by-count":57,"title":["Loading of MHC Class I and II Presentation Pathways by Exogenous Antigens: A Quantitative In Vivo Comparison"],"prefix":"10.1093","volume":"172","author":[{"given":"Tazio","family":"Storni","sequence":"first","affiliation":[{"name":"Cytos Biotechnology , AG, Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Cytos Biotechnology , AG, Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,5,15]]},"reference":[{"key":"2026020211270553500_R1","first-page":"199","volume-title":"Immunol. 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