{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:28:33Z","timestamp":1790983713001,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We used a PCR and sequence procedure to analyze the Ig VH gene and the mutations in the 5\u2032 regulatory regions of BCL-6 genes in pulmonary lymphoproliferative disorders (mucosa-associated lymphoid tissue (MALT) lymphoma, HIV-related, EBV-related, and virus-negative lymphocytic interstitial pneumonia (LIP)). Eight of 20 (40%) pulmonary MALT lymphoma and 10 of 20 LIP (5 of 5 (100%) HIV-related, 2 of 5 (40%) EBV-related, and 3 of 10 (30%) virus-negative LIP) cases showed BCL-6 gene mutations. Intraclonal heterogeneity of the BCL-6 mutations was observed only in pulmonary MALT lymphoma cases whose Ig VH genes also showed intraclonal heterogeneity. Ongoing BCL-6 mutations might reflect re-entry into a germinal center pathway to further mutations. BCL-6 mutations in pulmonary MALT lymphoma and HIV-negative LIP showed some features (high transition to transversion ratio, standard polarity, and RGYW\/WRCY bias) of Ig VH gene hypermutation, leading to the view that pulmonary MALT lymphomas and HIV-negative LIP are under the influence of germinal center hypermutation mechanisms. Because BCL-6 mutations in HIV-related LIP cases did not demonstrate features of Ig VH gene hypermutation, immunological reactions in HIV-related LIP are the result of a process different from that found in HIV-negative pulmonary lymphoproliferative disorders.<\/jats:p>","DOI":"10.4049\/jimmunol.172.11.7116","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:55:42Z","timestamp":1398030942000},"page":"7116-7122","source":"Crossref","is-referenced-by-count":4,"title":["BCL-6 Mutations in Pulmonary Lymphoproliferative Disorders: Demonstration of an Aberrant Immunological Reaction in HIV-Related Lymphoid Interstitial Pneumonia"],"prefix":"10.1093","volume":"172","author":[{"given":"Katsushi","family":"Kurosu","sequence":"first","affiliation":[{"name":"Department of Respirology (B2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Weiden","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine and Bellevue Chest Service, New York University Medical Center , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Department of Respirology (B2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William N","family":"Rom","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine and Bellevue Chest Service, New York University Medical Center , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Yumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagirdar","family":"Jaishree","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University Medical Center , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh","family":"Nakata","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine and Bellevue Chest Service, New York University Medical Center , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Respirology (B2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Respirology (B2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Respirology (B2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Mikata","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Respirology (B2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"2026020211254382200_R1","first-page":"794","volume-title":"Am. 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