{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:36:34Z","timestamp":1791164194250,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic infection by the gastrointestinal nematode Trichuris muris in susceptible AKR mice, which mount a Th1 response, is associated with IL-27p28 expression in the cecum. In contrast to wild-type mice, mice that lack the WSX-1\/IL-27R gene fail to harbor a chronic infection, having significantly lower Th1 responses. The lower level of Ag-specific IFN-\u03b3-positive cells in WSX-1 knockout (KO) mice was found to be CD4+ T cell specific, and the KO mice also had increased levels of IL-4-positive CD4+ T cells. Polyclonal activation of mesenteric lymph node cells from naive WSX-1 KO or wild-type mice demonstrated that there was no inherent defect in the production of IFN-\u03b3 by CD4+ T cells, suggesting the decrease in these cells seen in infected WSX-1 KO mice is an in vivo Ag-driven effect. IL-12 treatment of WSX-1 KO mice failed to rescue the type 1 response, resulting in unaltered type-2-driven resistance. Infection of WSX-1 KO mice was also associated with a reduction of IL-27\/WSX-1 downstream signaling gene expression within the cecum. These studies demonstrate an important role for WSX-1 signaling in the promotion of type 1 responses and chronic gastrointestinal nematode infection.<\/jats:p>","DOI":"10.4049\/jimmunol.172.12.7635","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:51:09Z","timestamp":1398127869000},"page":"7635-7641","source":"Crossref","is-referenced-by-count":42,"title":["WSX-1: A Key Role in Induction of Chronic Intestinal Nematode Infection"],"prefix":"10.1093","volume":"172","author":[{"given":"Allison J","family":"Bancroft","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Manchester , Manchester ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil E","family":"Humphreys","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Manchester , Manchester ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Worthington","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Manchester , Manchester ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Saga Medical School , Saga ,","place":["Japan"]},{"name":"PRESTO, Japan Science and Technology Agency , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K","family":"Grencis","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Manchester , Manchester ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,6,15]]},"reference":[{"key":"2026020211213156800_R1","first-page":"779","volume-title":"Immunity","year":"2002"},{"key":"2026020211213156800_R2","first-page":"82","volume-title":"Biochem. Biophys. Res. Commun.","year":"1998"},{"key":"2026020211213156800_R3","first-page":"916","volume-title":"Nature","year":"2000"},{"key":"2026020211213156800_R4","first-page":"569","volume-title":"Immunity","year":"2001"},{"key":"2026020211213156800_R5","first-page":"4886","volume-title":"J. Immunol.","year":"2003"},{"key":"2026020211213156800_R6","first-page":"655","volume-title":"Cell","year":"2000"},{"key":"2026020211213156800_R7","first-page":"301","volume-title":"Gut","year":"2002"},{"key":"2026020211213156800_R8","first-page":"645","volume-title":"Immunity","year":"2003"},{"key":"2026020211213156800_R9","first-page":"657","volume-title":"Immunity","year":"2003"},{"key":"2026020211213156800_R10","first-page":"508","volume-title":"Immunology","year":"1991"},{"key":"2026020211213156800_R11","first-page":"232","volume-title":"Immunology","year":"1992"},{"key":"2026020211213156800_R12","first-page":"3453","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020211213156800_R13","first-page":"347","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2026020211213156800_R14","first-page":"866","volume-title":"Eur. J. Immunol.","year":"1997"},{"key":"2026020211213156800_R15","first-page":"355","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026020211213156800_R16","first-page":"1627","volume-title":"Int. J. Parasitol.","year":"2001"},{"key":"2026020211213156800_R17","first-page":"4245","volume-title":"J. Immunol.","year":"1988"},{"key":"2026020211213156800_R18","first-page":"597","volume-title":"Cell","year":"1999"},{"key":"2026020211213156800_R19","first-page":"377","volume-title":"Immunity","year":"1999"},{"key":"2026020211213156800_R20","first-page":"1461","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026020211213156800_R21","first-page":"515","volume-title":"Parasitology","year":"1967"},{"key":"2026020211213156800_R22","first-page":"595","volume-title":"Parasite Immunol.","year":"1993"},{"key":"2026020211213156800_R23","first-page":"3113","volume-title":"Eur. J. Immunol.","year":"1994"},{"key":"2026020211213156800_R24","first-page":"303","volume-title":"Annu. Rev. Immunol.","year":"1990"},{"key":"2026020211213156800_R25","first-page":"527","volume-title":"Parasite Immunol.","year":"2002"},{"key":"2026020211213156800_R26","first-page":"2950","volume-title":"Infect. Immun.","year":"1996"},{"key":"2026020211213156800_R27","first-page":"2083","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2026020211213156800_R28","first-page":"15047","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026020211213156800_R29","first-page":"51","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020211213156800_R30","first-page":"2974","volume-title":"Eur. J. Immunol.","year":"2003"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/172\/12\/7635\/62597826\/7635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/172\/12\/7635\/62597826\/7635.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:21:37Z","timestamp":1770049297000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/172\/12\/7635\/8033681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":30,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2004,6,15]]},"published-print":{"date-parts":[[2004,6,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.172.12.7635","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,6]]},"published":{"date-parts":[[2004,6]]}}}