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Recently, CD8+ T cells, which are recruited to the lung in large numbers in response to PC infection, have been associated with some level of host defense as well as contributing to lung injury in BALB\/c mice. In this study, we show that CD8+ T cells that have a T cytotoxic-1 response to PC in BALB\/c mice, as determined by secretion of IFN-\u03b3, have in vitro killing activity against PC and effect clearance of the organism in adoptive transfer studies. Moreover, non-T cytotoxic-1 CD8+ T cells lacked in vitro effector activity and contributed to lung injury upon adoptive transfer. This dichotomous response in CD8+ T cell response may in part explain the clinical heterogeneity in the severity of PC pneumonia.<\/jats:p>","DOI":"10.4049\/jimmunol.172.2.1132","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:30:46Z","timestamp":1398025846000},"page":"1132-1138","source":"Crossref","is-referenced-by-count":68,"title":["T Cytotoxic-1 CD8+ T Cells Are Effector Cells against\n                    <i>Pneumocystis<\/i>\n                    in Mice"],"prefix":"10.1093","volume":"172","author":[{"given":"Florencia","family":"Mc Allister","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erana","family":"Young","sequence":"additional","affiliation":[{"name":"Gene Therapy Program, Louisiana State University Health Sciences Center, School of Medicine , New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judd E","family":"Shellito","sequence":"additional","affiliation":[{"name":"Gene Therapy Program, Louisiana State University Health Sciences Center, School of Medicine , New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Marrero","sequence":"additional","affiliation":[{"name":"Gene Therapy Program, Louisiana State University Health Sciences Center, School of Medicine , New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,1,15]]},"reference":[{"key":"2026020214134640800_R1","first-page":"92","volume-title":"Ann. 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