{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:58:59Z","timestamp":1789966739744,"version":"4.0.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To study liver cell damage by CTL, CD8 T cells from P14 TCR transgenic (tg) mice specific for the gp33 epitope of lymphocytic choriomeningitis virus with either deficiency in IFN-\u03b3 (P14.IFN-\u03b3\u00b0), functional Fas ligand (P14.gld), or perforin (P14.PKO) were transferred into H8 tg mice ubiquitously expressing gp33 Ag. Treatment of H8 recipient mice with agonistic anti-CD40 Abs induced vigorous expansion of the transferred P14 T cells and led to liver cell destruction determined by increase of glutamate dehydrogenase serum levels and induction of caspase-3 in hepatocytes. Liver injury was mediated by the Fas\/Fas ligand (FasL) pathway and by perforin, because P14.gld and P14.PKO T cells failed to induce increased glutamate dehydrogenase levels despite strong in vivo proliferation. In addition, H8 tg mice lacking Fas were resistant to the pathogenic effect of P14 T cells. Besides FasL and perforin, IFN-\u03b3 was also required for liver cell damage, because P14.IFN-\u03b3\u00b0 T cells adoptively transferred into H8 mice failed to induce disease. Moreover, Fas expression on hepatocytes from H8 recipient mice was increased after transfer of wild-type compared with P14.IFN-\u03b3\u00b0 T cells, and wild-type P14 T cells expressed higher levels of FasL than P14 T cells lacking IFN-\u03b3. Thus, our data suggest that IFN-\u03b3 released by activated CD8 T cells upon Ag contact facilitates liver cell destruction.<\/jats:p>","DOI":"10.4049\/jimmunol.172.3.1588","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:08:36Z","timestamp":1398028116000},"page":"1588-1594","source":"Crossref","is-referenced-by-count":53,"title":["IFN-\u03b3 Promotes Fas Ligand- and Perforin-Mediated Liver Cell Destruction by Cytotoxic CD8 T Cells"],"prefix":"10.1093","volume":"172","author":[{"given":"Evelyn","family":"Roth","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,2,1]]},"reference":[{"key":"2026020211202612000_R1","first-page":"474","volume-title":"Nature","year":"1998"},{"key":"2026020211202612000_R2","first-page":"478","volume-title":"Nature","year":"1998"},{"key":"2026020211202612000_R3","first-page":"480","volume-title":"Nature","year":"1998"},{"key":"2026020211202612000_R4","first-page":"774","volume-title":"Nat. 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