{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:51:33Z","timestamp":1791294693138,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the in vivo function of Fas ligand (FasL), we produced a mouse strain with a FasL gene flanked by loxP sequences. Mice with homozygous floxed FasL gene showed no obvious abnormalities. However, germline deletion of the FasL gene, obtained after mating with mice expressing ubiquitous Cre recombinase, resulted in an unexpectedly severe phenotype. FasL\u2212\/\u2212 mice exhibited an extreme splenomegaly and lymphadenopathy associated with lymphocytic infiltration into multiple organs and autoimmune disease. This severe phenotype led to the premature death at 4 mo of age of &amp;gt;50% of the homozygous mice. It stands in sharp contrast with the milder disease observed in gld (generalized lymphoproliferative disease) mice, indicating that the FasL allele of these mice encodes a protein still able to bind, albeit at a very low level, the Fas receptor.<\/jats:p>","DOI":"10.4049\/jimmunol.172.4.2118","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T23:33:57Z","timestamp":1398209637000},"page":"2118-2125","source":"Crossref","is-referenced-by-count":67,"title":["Complete Loss of\n                    <i>Fas Ligand<\/i>\n                    Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of\n                    <i>gld<\/i>\n                    Allele"],"prefix":"10.1093","volume":"172","author":[{"given":"Saoussen","family":"Karray","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 580, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Kress","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie du De\u0301veloppement, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Cuvellier","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 580, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Hue-Beauvais","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 580, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Damotte","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomie Pathologique, Ho\u0302pital Europe\u0301en Georges Pompidou , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Babinet","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie du De\u0301veloppement, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Le\u0301vi-Strauss","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 580, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,2,15]]},"reference":[{"key":"2026020211215046800_R1","first-page":"1449","volume-title":"Science","year":"1995"},{"key":"2026020211215046800_R2","first-page":"243","volume-title":"Annu. 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