{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:59:58Z","timestamp":1791478798366,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12. Previously reported IL-12p40-deficient mice have profound immune defects resulting from combined deficiency in both IL-12 and IL-23. To address the effects of specific IL-23 deficiency, we generated mice lacking p19 by gene targeting. These mice display no overt abnormalities but mount severely compromised T-dependent humoral immune responses. IL-23p19\u2212\/\u2212 mice produce strongly reduced levels of Ag-specific Igs of all isotypes, but mount normal T-independent B cell responses. In addition, delayed type hypersensitivity responses are strongly impaired in the absence of IL-23, indicating a defect at the level of memory T cells. T cells stimulated with IL-23-deficient APCs secrete significantly reduced amounts of the proinflammatory cytokine IL-17, and IL-23-deficient mice phenotypically resemble IL-17-deficient animals. Thus, IL-23 plays a critical role in T cell-dependent immune responses, and our data provide further support for the existence of an IL-23\/IL-17 axis of communication between the adaptive and innate parts of the immune system.<\/jats:p>","DOI":"10.4049\/jimmunol.172.5.2827","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T03:21:06Z","timestamp":1398050466000},"page":"2827-2833","source":"Crossref","is-referenced-by-count":154,"title":["Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice"],"prefix":"10.1093","volume":"172","author":[{"given":"Nico","family":"Ghilardi","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Genentech , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelyn","family":"Kljavin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Process Sciences, Genentech , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin L","family":"Gurney","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech , South San Francisco, CA 94080"},{"name":"Department of Immunology, Genentech , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic J","family":"de Sauvage","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"2025032707435379700_R1","first-page":"715","volume-title":"Immunity","year":"2000"},{"key":"2025032707435379700_R2","first-page":"133","volume-title":"Nat. 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