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We isolated epitope-specific T cells with an IFN-\u03b3 capture assay or MHC class I\/peptide tetramers and identified different clonotypes by V\u03b2 chain sequence analysis. In agreement with our previous results, the number of different clonotypes responding to all three epitopes fit a log-series distribution. From these distributions, we estimated that &amp;gt;1000 different clonotypes responded to each immunodominant CD8 T cell epitope; the response to a subdominant CD8 T cell epitope was modestly less diverse. These results suggest that T cell response diversity is greater by 1\u20132 orders of magnitude than predicted previously.<\/jats:p>","DOI":"10.4049\/jimmunol.172.5.3151","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T03:21:06Z","timestamp":1398050466000},"page":"3151-3156","source":"Crossref","is-referenced-by-count":46,"title":["Very Diverse CD8 T Cell Clonotypic Responses after Virus Infections"],"prefix":"10.1093","volume":"172","author":[{"given":"Lecia L","family":"Pewe","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M","family":"Netland","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B","family":"Heard","sequence":"additional","affiliation":[{"name":"Department of Biology, University of New Brunswick , Fredericton, New Brunswick ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Perlman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"2025032707431526900_R1","first-page":"475","volume-title":"Annu. 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