{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:29:46Z","timestamp":1790936986750,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunization of mice with nonviable Listeria monocytogenes generates an insufficient CD8+ T cell response and consequently only limited protection against subsequent L. monocytogenes infection. We have recently demonstrated that depletion of regulatory CD4+ T cells during immunization significantly enhances CD8+ T cell responses. In the present study, we determined the impact of CD4+ T cell depletion on the CD8+ T cell response against heat-killed Listeria. Treatment of mice with anti-CD4 mAb during boost immunization with heat-killed Listeria significantly increased numbers of Listeria-specific CD8+ T cells and improved protection against subsequent infection with L. monocytogenes. During challenge infection, numbers of Listeria-specific CD8+ T cells were enhanced, and these cells expressed effector functions in terms of IFN-\u03b3 production. In summary, we demonstrate that combining nonviable L. monocytogenes vaccination and CD4+ T cell depletion improves generation of long-lasting and functional Listeria-specific CD8+ memory T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.172.5.3167","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:21:06Z","timestamp":1398036066000},"page":"3167-3172","source":"Crossref","is-referenced-by-count":25,"title":["Depletion of CD4+ T Cells during Immunization with Nonviable\n                    <i>Listeria monocytogenes<\/i>\n                    Causes Enhanced CD8+ T Cell-Mediated Protection against Listeriosis"],"prefix":"10.1093","volume":"172","author":[{"given":"Mischo","family":"Kursar","sequence":"first","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Ko\u0308hler","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H E","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Willi","family":"Mittru\u0308cker","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"2026020214132255700_R1","first-page":"129","volume-title":"Annu. 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