{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:26:52Z","timestamp":1771000012427,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ocular infection with HSV may result in the blinding immunoinflammatory lesion stromal keratitis (SK). This represents a CD4+ T cell-mediated immunopathologic lesion in both humans and a mouse model. Early events in the pathogenesis that set the stage for SK are poorly understood. The present study evaluates the role of IL-1 using a transgenic mouse that overexpresses the IL-1 receptor antagonist (IL-1ra) protein. Such transgenic mice were markedly resistant to SK compared with IL-1ra\u2212\/\u2212 and C57BL\/6 control animals. The resistance was shown to be the consequence of reduced expression of molecules such as IL-6, macrophage-inflammatory protein-2, and vascular endothelial growth factor, normally up-regulated directly or indirectly by IL-1. A critical event impaired in IL-1ra transgenic mice was vascular endothelial growth factor production with a consequent marked reduction in angiogenesis, an essential step in SK pathogenesis. Targeting IL-1 could prove to be a worthwhile therapeutic approach to control SK, an important cause of human blindness.<\/jats:p>","DOI":"10.4049\/jimmunol.172.6.3736","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:59:29Z","timestamp":1398031169000},"page":"3736-3744","source":"Crossref","is-referenced-by-count":48,"title":["Mice Transgenic for IL-1 Receptor Antagonist Protein Are Resistant to Herpetic Stromal Keratitis: Possible Role for IL-1 in Herpetic Stromal Keratitis Pathogenesis"],"prefix":"10.1093","volume":"172","author":[{"given":"Partha S","family":"Biswas","sequence":"first","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaustuv","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bumseok","family":"Kim","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry T","family":"Rouse","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,3,15]]},"reference":[{"key":"2026020211202113500_R1","first-page":"443","volume-title":"Immunol. 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