{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:54:35Z","timestamp":1791420875069,"version":"4.3.3"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Protein complexes of the 28-kDa proteasome activator (PA28) family activate the proteasome and may alter proteasome cleavage specificity. Initial investigations have demonstrated a role for the IFN-\u03b3-inducible PA28\u03b1\/\u03b2 complex in Ag processing. Although the noninducible and predominantly nuclear PA28\u03b3 complex has been implicated in affecting proteasome-dependent signaling pathways, such as control of the mitotic cell cycle, there is no previous evidence demonstrating a role for this structure in Ag processing. We therefore generated PA28\u03b3-deficient mice and investigated their immune function. PA28\u03b3\u2212\/\u2212 mice display a slight reduction in CD8+ T cell numbers and do not effectively clear a pulmonary fungal infection. However, T cell responses in two viral infection models appear normal in both magnitude and the hierarchy of antigenic epitopes recognized. We conclude that PA28\u03b3\u2212\/\u2212 mice, like PA28\u03b1\u2212\/\u2212\/\u03b2\u2212\/\u2212 mice, are deficient in the processing of only specific Ags.<\/jats:p>","DOI":"10.4049\/jimmunol.172.6.3948","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:59:29Z","timestamp":1398031169000},"page":"3948-3954","source":"Crossref","is-referenced-by-count":105,"title":["Immune Defects in 28-kDa Proteasome Activator \u03b3-Deficient Mice"],"prefix":"10.1093","volume":"172","author":[{"given":"Lance F","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert A","family":"Runnels","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati , Cincinnati, OH 45267"},{"name":"Howard Hughes Medical Institute, University of Cincinnati , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd D","family":"Schell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University, Milton S. 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