{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:06:30Z","timestamp":1772723190650,"version":"3.50.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lymphoid organogenesis is a highly coordinated process involving orchestrated expression of a number of genes. Although the essential role of lymphotoxin \u03b1 (LT\u03b1) for the normal development of secondary lymphoid organs is well established, it is not clear to which extent it depends upon cooperation with T and B lymphocytes for lymphoid neo-organogenesis. To determine whether LT\u03b1 is sufficient to mediate recruitment of basic elements needed for lymphoid organogenesis, we made use of a LT\u03b1-transfected cell line as an experimental tool and established tumors in nude and SCID mice. Our data showed that high endothelial venules formed and follicular dendritic cells accumulated and differentiated in response to LT\u03b1 in the absence of lymphocytes. A CD4+CD3\u2212CD11c+ cell population that is found in the secondary lymphoid organ was also recruited into tumors expressing LT\u03b1. Furthermore, in nude mice, B cells migrated in response to LT\u03b1 and formed intratumoral follicles. These B cell follicles were structurally well equipped with follicular dendritic cell networks and high endothelial venules; however, they were not functionally active; e.g., those B cells specific for a surrogate Ag expressed by the tumor were found in the spleen, but not in the tumor. We show that, even in the absence of functional T and B lymphocytes, local expression of LT\u03b1 in transplanted tumors induced typical stromal characteristics of lymphoid tissue, emphasizing that LT\u03b1 is a critically important cytokine for formation of lymphoid organ infrastructure.<\/jats:p>","DOI":"10.4049\/jimmunol.172.7.4037","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:56:20Z","timestamp":1398045380000},"page":"4037-4047","source":"Crossref","is-referenced-by-count":22,"title":["Establishment of Early Lymphoid Organ Infrastructure in Transplanted Tumors Mediated by Local Production of Lymphotoxin \u03b1 and in the Combined Absence of Functional B and T Cells"],"prefix":"10.1093","volume":"172","author":[{"given":"Hye-Jung","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of Immunology, Charite\u0301 Campus Benjamin Franklin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kammertoens","sequence":"additional","affiliation":[{"name":"Max Delbru\u0308ck Center for Molecular Medicine , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Janke","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma ForschungsZentrum , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Schmetzer","sequence":"additional","affiliation":[{"name":"Max Delbru\u0308ck Center for Molecular Medicine , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihai","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Charite\u0301 Campus Benjamin Franklin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Berek","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma ForschungsZentrum , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Blankenstein","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Charite\u0301 Campus Benjamin Franklin , Berlin ,","place":["Germany"]},{"name":"Max Delbru\u0308ck Center for Molecular Medicine , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,4,1]]},"reference":[{"key":"2025032707492569900_R1","first-page":"329","volume-title":"Eur. 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