{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:25:44Z","timestamp":1790889944816,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent studies have suggested the IL-4R\u03b1 expressed on lung epithelium is necessary for TH2-mediated goblet cell differentiation and mucus hypersecretion in a murine model of allergic lung disease. However, the IL-4R\u03b1 is expressed on numerous cell types that could contribute to the overall pathology and severity of asthma. The relative role of the receptor on these cells has not yet been conclusively delineated. To dissect the contribution of IL-4R\u03b1 in the development of pulmonary allergic responses, we generated murine radiation bone marrow (BM) chimeras. BM from IL-4R\u03b1+ or IL-4R\u03b1\u2212 mice was transferred into recipient mice that expressed or lacked IL-4R\u03b1. In the absence of IL-4R\u03b1 in recipient mice, there was no goblet cell metaplasia or mucus hypersecretion in response to OVA, even in the presence of TH2 cells and substantial eosinophilic infiltration. More importantly, we found that expression of the IL-4R\u03b1 on a nonlymphoid, MHC class II+, BM-derived cell type contributes to the severity of inflammation and mucus production. These results suggest that IL-4 and IL-13 contribute to the development of allergic inflammation by stimulating a complex interaction between IL-4R\u03b1+ cell types of both bone marrow and non-bone marrow origin.<\/jats:p>","DOI":"10.4049\/jimmunol.172.7.4545","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:56:20Z","timestamp":1398030980000},"page":"4545-4555","source":"Crossref","is-referenced-by-count":57,"title":["Complex Role of the IL-4 Receptor \u03b1 in a Murine Model of Airway Inflammation: Expression of the IL-4 Receptor \u03b1 on Nonlymphoid Cells of Bone Marrow Origin Contributes to Severity of Inflammation"],"prefix":"10.1093","volume":"172","author":[{"given":"Ann E","family":"Kelly-Welch","sequence":"first","affiliation":[{"name":"Departments of Immunology, American Red Cross , Rockville, MD 20855"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco E F","family":"Melo","sequence":"additional","affiliation":[{"name":"Departments of Immunology, American Red Cross , Rockville, MD 20855"},{"name":"Department of Immunology, George Washington University Medical Center , Washington, D.C. 20037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Holland Laboratory, American Red Cross , Rockville, MD 20855"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Q","family":"Ford","sequence":"additional","affiliation":[{"name":"Departments of Immunology, American Red Cross , Rockville, MD 20855"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haudenschild","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Holland Laboratory, American Red Cross , Rockville, MD 20855"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Noben-Trauth","sequence":"additional","affiliation":[{"name":"Department of Immunology, George Washington University Medical Center , Washington, D.C. 20037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achsah D","family":"Keegan","sequence":"additional","affiliation":[{"name":"Departments of Immunology, American Red Cross , Rockville, MD 20855"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,4,1]]},"reference":[{"key":"2026020214121694200_R1","first-page":"255","volume-title":"Annu. 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