{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:00Z","timestamp":1790834580710,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Positive selection by autoantigens is believed to play an important role in the generation\/maintenance of B-1a cells. Recently, it has been described that splenectomy results in the loss of an already established B-1a cell pool. To elucidate whether the spleen influences the peritoneal B-1a repertoire, we have analyzed the consequences of splenectomy in the recently established IgL-transgenic L2 mouse model. L2 mice are characterized by a severe block of B-2 development and predominance of B-1a cells, which exhibit a pronounced IgH oligoclonality, presumably due to positive selection by autoantigens. In this study, we show that, in striking contrast to splenectomized normal mice, L2 mice exhibit unchanged frequencies of peritoneal B-1a cells. The IgH repertoire of these B-1a cells, however, was severely perturbed in that the previously described predominant B-1a H chains were no longer present. The repertoire changes were partial since phosphatidylcholine-specific B-1a cells were present in similar numbers before and after splenectomy. Thus, splenic Ags appear to act as \u201csurvival factors\u201d for major subsets of peritoneal B cells. The loss of B-1a cells in the absence of such factors is compensated by repertoire changes among B-1a cells in B cell lymphopenic L2 but not normal mice.<\/jats:p>","DOI":"10.4049\/jimmunol.173.1.197","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:09:13Z","timestamp":1398028153000},"page":"197-204","source":"Crossref","is-referenced-by-count":21,"title":["Maintenance of Peritoneal B-1a Lymphocytes in the Absence of the Spleen"],"prefix":"10.1093","volume":"173","author":[{"given":"Karsten","family":"Kretschmer","sequence":"first","affiliation":[{"name":"Molecular Immunology, Gesellschaft fu\u0308r Biotechnologische Forschung, German Research Centre for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Stopkowicz","sequence":"additional","affiliation":[{"name":"Molecular Immunology, Gesellschaft fu\u0308r Biotechnologische Forschung, German Research Centre for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Scheffer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim F","family":"Greten","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Weiss","sequence":"additional","affiliation":[{"name":"Molecular Immunology, Gesellschaft fu\u0308r Biotechnologische Forschung, German Research Centre for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"2026020212073045900_R1","first-page":"253","volume-title":"Annu. 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