{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:17:37Z","timestamp":1790907457619,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD25+ T regulatory (Treg) cells play a central role regarding the maintenance of peripheral tolerance via suppression of autoaggressive CD4+ T cells, CD8+ T cells, and Th1 cells. In this study we demonstrate that CD25+ Treg cells can also suppress the differentiation of murine conventional CD4+ T cells toward Th2 cells in a contact-dependent manner. However, the cytokine production and proliferation of established Th2 cells could not be inhibited by freshly isolated CD25+ Treg cells, whereas a strong inhibition of differentiated Th2 cells by in vitro preactivated CD25+ Treg cells could be observed. Inhibition of both conventional CD4+ T cells and Th2 cells is accompanied by a strong enhancement of the expression of FoxP3 in the suppressed T cells. Hence, our study indicates that CD25+ Treg cells have a therapeutic potential for Th2-mediated diseases and suggests a novel mechanism of suppression mediated by the transcriptional repressor FoxP3.<\/jats:p>","DOI":"10.4049\/jimmunol.173.1.267","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:09:13Z","timestamp":1398028153000},"page":"267-274","source":"Crossref","is-referenced-by-count":79,"title":["Differential Regulatory Capacity of CD25+ T Regulatory Cells and Preactivated CD25+ T Regulatory Cells on Development, Functional Activation, and Proliferation of Th2 Cells"],"prefix":"10.1093","volume":"173","author":[{"given":"Michael","family":"Stassen","sequence":"first","affiliation":[{"name":"Institute of Immunology, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Jonuleit","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mu\u0308ller","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Richter","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Bopp","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Center for Natural Sciences and Medicine, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"2026020212063587200_R1","first-page":"455","volume-title":"Cell","year":"2000"},{"key":"2026020212063587200_R2","first-page":"423","volume-title":"Annu. 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