{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:00:14Z","timestamp":1792735214409,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Leukocyte cell-derived chemotaxin 2 (LECT2) was originally identified for its possible chemotactic activity against human neutrophils in vitro. It is a 16-kDa protein that is preferentially expressed in the liver. Its homologues have been widely identified in many vertebrates. Current evidence suggests that LECT2 may be a multifunctional protein like cytokines. However, the function of LECT2 in vivo remains unclear. To elucidate the role of this protein in vivo, we have generated LECT2-deficient (LECT2\u2212\/\u2212) mice. We found that the proportion of NKT cells in the liver increased significantly in LECT2\u2212\/\u2212 mice, although those of conventional T cells, NK cells, and other cell types were comparable with those in wild-type mice. Consistent with increased hepatic NKT cell number, the production of IL-4 and IFN-\u03b3 was augmented in LECT2\u2212\/\u2212 mice upon stimulation with \u03b1-galactosylceramide, which specifically activates V\u03b114 NKT cells. In addition, NKT cell-mediated cytotoxic activity against syngeneic thymocytes increased in hepatic mononuclear cells obtained from LECT2\u2212\/\u2212 mice in vitro. Interestingly, the hepatic injury was exacerbated in LECT2\u2212\/\u2212 mice upon treatment with Con A, possibly because of the significantly higher expression of IL-4 and Fas ligand. These results suggest that LECT2 might regulate the homeostasis of NKT cells in the liver and might be involved in the pathogenesis of hepatitis.<\/jats:p>","DOI":"10.4049\/jimmunol.173.1.579","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:09:13Z","timestamp":1398028153000},"page":"579-585","source":"Crossref","is-referenced-by-count":79,"title":["Increase in Hepatic NKT Cells in Leukocyte Cell-Derived Chemotaxin 2-Deficient Mice Contributes to Severe Concanavalin A-Induced Hepatitis"],"prefix":"10.1093","volume":"173","author":[{"given":"Takeshi","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Bioactive Molecules, National Institute of Infectious Diseases , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Bioactive Molecules, National Institute of Infectious Diseases , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisami","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Immunology, Center of Molecular Biosciences, University of Ryukyus , Okinawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Asano","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Ishida-Okawara","sequence":"additional","affiliation":[{"name":"Department of Bioactive Molecules, National Institute of Infectious Diseases , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuko","family":"Sudo","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Hatano-Yokoe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Showa University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena S","family":"Bezbradica","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Abo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Niigata University School of Medicine , Niigata ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Bioactive Molecules, National Institute of Infectious Diseases , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamagoe","sequence":"additional","affiliation":[{"name":"Department of Bioactive Molecules, National Institute of Infectious Diseases , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"2026020212044004500_R1","first-page":"9","volume-title":"Immunol. Lett.","year":"1996"},{"key":"2026020212044004500_R2","first-page":"105","volume-title":"Biochim. Biophys. Acta","year":"1998"},{"key":"2026020212044004500_R3","first-page":"425","volume-title":"Biol. Pharm. Bull.","year":"2001"},{"key":"2026020212044004500_R4","first-page":"1115","volume-title":"Cell","year":"1989"},{"key":"2026020212044004500_R5","first-page":"643","volume-title":"Fish Shellfish Immunol.","year":"2000"},{"key":"2026020212044004500_R6","first-page":"22657","volume-title":"J. Biol. Chem.","year":"1996"},{"key":"2026020212044004500_R7","first-page":"1419","volume-title":"Arthritis Rheum.","year":"2000"},{"key":"2026020212044004500_R8","first-page":"196","volume-title":"J. Clin. Invest.","year":"1992"},{"key":"2026020212044004500_R9","first-page":"367","volume-title":"Curr. Opin. Immunol.","year":"1995"},{"key":"2026020212044004500_R10","first-page":"535","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026020212044004500_R11","first-page":"633","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020212044004500_R12","first-page":"573","volume-title":"Immunol. Today","year":"2000"},{"key":"2026020212044004500_R13","first-page":"135","volume-title":"Immunol. Rev.","year":"2000"},{"key":"2026020212044004500_R14","first-page":"1537","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020212044004500_R15","first-page":"105","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020212044004500_R16","first-page":"5498","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020212044004500_R17","first-page":"171","volume-title":"Gene","year":"1998"},{"key":"2026020212044004500_R18","first-page":"693","volume-title":"Cell","year":"1991"},{"key":"2026020212044004500_R19","first-page":"1463","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020212044004500_R20","first-page":"145","volume-title":"J. Immunol. Methods","year":"1992"},{"key":"2026020212044004500_R21","first-page":"1849","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026020212044004500_R22","first-page":"219","volume-title":"Immunology","year":"1997"},{"key":"2026020212044004500_R23","first-page":"1895","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020212044004500_R24","first-page":"741","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020212044004500_R25","first-page":"1626","volume-title":"Science","year":"1997"},{"key":"2026020212044004500_R26","first-page":"1919","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2026020212044004500_R27","first-page":"43","volume-title":"Cell. Immunol.","year":"2002"},{"key":"2026020212044004500_R28","first-page":"1720","volume-title":"Eur. J. Immunol.","year":"2001"},{"key":"2026020212044004500_R29","first-page":"1529","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2026020212044004500_R30","first-page":"4647","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020212044004500_R31","first-page":"190","volume-title":"Hepatology","year":"1995"},{"key":"2026020212044004500_R32","first-page":"5112","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020212044004500_R33","first-page":"10913","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026020212044004500_R34","first-page":"4020","volume-title":"J. Immunol.","year":"2003"},{"key":"2026020212044004500_R35","first-page":"364","volume-title":"Trends Immunol.","year":"2003"},{"key":"2026020212044004500_R36","first-page":"557","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020212044004500_R37","first-page":"3749","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020212044004500_R38","first-page":"625","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020212044004500_R39","first-page":"637","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020212044004500_R40","first-page":"2240","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020212044004500_R41","first-page":"835","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020212044004500_R42","first-page":"553","volume-title":"Science","year":"2002"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/1\/579\/62604610\/579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/1\/579\/62604610\/579.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:04:51Z","timestamp":1770051891000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/173\/1\/579\/8034971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,7,1]]},"published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.173.1.579","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,7]]},"published":{"date-parts":[[2004,7,1]]}}}