{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:19:53Z","timestamp":1791332393823,"version":"4.3.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allergy involves eosinophilia and Th2 polarization. Indoleamine 2,3-dioxygenase (IDO)-catalyzed conversion of tryptophan to kynurenines (KYN) regulates T cell function. We show that human eosinophils constitutively express IDO. Eosinophils treated with IFN-\u03b3 showed an 8-fold increase in IDO mRNA within 4 h; IL-3, IL-5, and GM-CSF had no effect on baseline IDO expression. IL-3 pretreatment of eosinophils reduced IFN-\u03b3-induced IDO mRNA expression below baseline. Conversely, GM-CSF, but not IL-5, resulted in a 2-fold increase in IFN-\u03b3-induced IDO. Treatment with IL-3, IL-5, GM-CSF, or IFN-\u03b3 alone expressed IDO enzymatic activity (the presence of KYN in supernatants 48 h postculture). CD28 cross-linking resulted in measurable KYN in culture supernatants, inhibitable by a neutralizing anti-IFN-\u03b3. Coculture of eosinophils with an IFN-\u03b3-producing T cell line, but not IL-4-producing T cell clone, led to apoptosis and inhibition of CD3 or CD3\/CD28-induced proliferation. Eosinophils infiltrating asthmatic lung and associated lymphoid tissue exhibited intracellular IDO immunoreactivity. Eosinophils may, therefore, maintain Th2 bias through IDO.<\/jats:p>","DOI":"10.4049\/jimmunol.173.10.5909","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:57:23Z","timestamp":1398027443000},"page":"5909-5913","source":"Crossref","is-referenced-by-count":176,"title":["Cutting Edge: Human Eosinophils Regulate T Cell Subset Selection through Indoleamine 2,3-Dioxygenase"],"prefix":"10.1093","volume":"173","author":[{"given":"Solomon O","family":"Odemuyiwa","sequence":"first","affiliation":[{"name":"Department of Medicine (Pulmonary Research Group), University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Ghahary","sequence":"additional","affiliation":[{"name":"Department of Medicine (Pulmonary Research Group), University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Puttagunta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine (Pulmonary Research Group), University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Musat-Marcu","sequence":"additional","affiliation":[{"name":"Histobest Laboratories, University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Ghahary","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redwan","family":"Moqbel","sequence":"additional","affiliation":[{"name":"Department of Medicine (Pulmonary Research Group), University of Alberta , Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,15]]},"reference":[{"key":"2026020214112540600_R1","first-page":"447","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020214112540600_R2","first-page":"1097","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2026020214112540600_R3","first-page":"1069","volume-title":"Cell Death Differ.","year":"2002"},{"key":"2026020214112540600_R4","first-page":"1762","volume-title":"Gastroenterology","year":"2003"},{"key":"2026020214112540600_R5","first-page":"405","volume-title":"Nat. Rev. Immunol.","year":"2003"},{"key":"2026020214112540600_R6","first-page":"1026","volume-title":"FASEB J.","year":"2003"},{"key":"2026020214112540600_R7","first-page":"227","volume-title":"Curr. Opin. Pharmacol.","year":"2003"},{"key":"2026020214112540600_R8","first-page":"923","volume-title":"J. Allergy Clin. Immunol.","year":"2003"},{"key":"2026020214112540600_R9","first-page":"945","volume-title":"J. Clin. Invest.","year":"2000"},{"key":"2026020214112540600_R10","first-page":"487","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020214112540600_R11","first-page":"206","volume-title":"J. Cell Biochem.","year":"2003"},{"key":"2026020214112540600_R12","first-page":"299","volume-title":"J. Allergy Clin. Immunol.","year":"2002"},{"key":"2026020214112540600_R13","first-page":"178","volume-title":"Anal. Biochem.","year":"2002"},{"key":"2026020214112540600_R14","first-page":"17161","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026020214112540600_R15","first-page":"65","volume-title":"Int. Immunol.","year":"2002"},{"key":"2026020214112540600_R16","first-page":"6332","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020214112540600_R17","first-page":"1408","volume-title":"Blood","year":"1994"},{"key":"2026020214112540600_R18","first-page":"533","volume-title":"Adv. Exp. Med. Biol.","year":"1999"},{"key":"2026020214112540600_R19","first-page":"617","volume-title":"J. Interferon Cytokine Res.","year":"1995"},{"key":"2026020214112540600_R20","first-page":"387","volume-title":"J. Interferon Cytokine Res.","year":"1997"},{"key":"2026020214112540600_R21","first-page":"247","volume-title":"Clin. Exp. Immunol.","year":"2003"},{"key":"2026020214112540600_R22","first-page":"415","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020214112540600_R23","first-page":"3296","volume-title":"J. Immunol.","year":"2003"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/10\/5909\/62608874\/5909.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/10\/5909\/62608874\/5909.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:18:15Z","timestamp":1770059895000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/173\/10\/5909\/8060000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":23,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2004,11,15]]},"published-print":{"date-parts":[[2004,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.173.10.5909","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,11]]},"published":{"date-parts":[[2004,11]]}}}