{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:28:35Z","timestamp":1791062915497,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The T-box transcription factor T-bet is an important regulator of IFN-\u03b3 production in all cell types and is considered to be essential for the generation of CD4 Th1 T cells. IFN-\u03b3 in turn plays a critical role in immunity to many infectious agents. In this study, we demonstrate that T-bet is not required for host resistance to primary Listeria monocytogenes (LM) infection. In the innate immune phase, control of LM replication, serum IFN-\u03b3, and numbers of IFN-\u03b3-producing NK cells were similar in T-bet-deficient and control mice. In the adaptive immune phase, there was no defect in bacterial clearance or in the numbers of LM-specific IFN-\u03b3-producing CD8 T cells in T-bet-deficient mice and only a modest, although significant, reduction in the numbers of Th1 CD4 T cells and IFN-\u03b3 secretion by CD4 T cells. Thus, host resistance and the generation of IFN-\u03b3-producing cells in response to LM infection are not substantially compromised in the absence of T-bet.<\/jats:p>","DOI":"10.4049\/jimmunol.173.10.5918","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:57:23Z","timestamp":1398027443000},"page":"5918-5922","source":"Crossref","is-referenced-by-count":43,"title":["Cutting Edge: Immunity and IFN-\u03b3 Production during\n                    <i>Listeria monocytogenes<\/i>\n                    Infection in the Absence of T-bet"],"prefix":"10.1093","volume":"173","author":[{"given":"Sing Sing","family":"Way","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Department of Immunology, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,15]]},"reference":[{"key":"2026020214111313200_R1","first-page":"2892","volume-title":"Infect. 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