{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:04:01Z","timestamp":1790935441229,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pax5 encodes BSAP, a member of the paired box domain transcription factors, whose expression is restricted to B lymphocyte lineage cells. Pax5\u2212\/\u2212 mice have a developmental arrest of the B cell lineage at the pro-B cell stage. We show here that Pax5\u2212\/\u2212 mice are severely osteopenic, missing 60% of their bone mass. The osteopenia can be accounted for by a &amp;gt;100% increase in the number of osteoclasts in bone measured histomorphometrically. This is not due to a lack of B cells, because other strains of B cell-deficient mice do not exhibit this phenotype. There was no difference in the number of osteoclasts produced in vitro by wild-type and Pax5\u2212\/\u2212 bone marrow cells. In contrast, spleen cells from Pax5\u2212\/\u2212 mice produce as much as five times the number of osteoclasts as control spleen cells. Culture of Pax5\u2212\/\u2212 spleen cells yields a population of adherent cells that grow spontaneously in culture without added growth factors for &amp;gt;4 wk. These cells have a monocyte phenotype, produce large numbers of osteoclasts when induced in vitro, and therefore are highly enriched in osteoclast precursors. These data demonstrate a previously unsuspected connection between B cell and osteoclast development and a key role for Pax5 in the control of osteoclast development.<\/jats:p>","DOI":"10.4049\/jimmunol.173.11.6583","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T04:54:49Z","timestamp":1398142489000},"page":"6583-6591","source":"Crossref","is-referenced-by-count":57,"title":["Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors"],"prefix":"10.1093","volume":"173","author":[{"given":"Mark C","family":"Horowitz","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yougen","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Pflugh","sequence":"additional","affiliation":[{"name":"Section of Immunobiology, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G T","family":"Hesslein","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Schatz","sequence":"additional","affiliation":[{"name":"Section of Immunobiology, Yale University School of Medicine , New Haven, CT 06510"},{"name":"Howard Hughes Medical Institute, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred L M","family":"Bothwell","sequence":"additional","affiliation":[{"name":"Section of Immunobiology, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"2025032707165223600_R1","first-page":"165","volume-title":"Cell","year":"1998"},{"key":"2025032707165223600_R2","first-page":"3597","volume-title":"Proc. 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