{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:32:54Z","timestamp":1790382774410,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Induction of immunological tolerance is highly desirable for the treatment and prevention of autoimmunity, allergy, and organ transplant rejection. Adoptive transfer of MHC class I disparate mature T cells at the time of reconstitution of mice with syngeneic bone marrow resulted in specific tolerance to allogeneic skin grafts that were matched to the T cell donor strain. Mature allogeneic T cells survived long-term in reconstituted hosts and were able to re-enter the thymus. Analysis of T cell development using transgenic mice expressing an alloantigen-reactive TCR revealed that expression of allogeneic MHC class I on adoptively transferred mature T cells mediated negative selection of developing alloreactive T cells in the thymus. Thus, mature allogeneic T cells are able to mediate central deletion of alloreactive cells and induce transplantation tolerance without the requirement for any other alloantigen-expressing cell type.<\/jats:p>","DOI":"10.4049\/jimmunol.173.12.7217","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:18:22Z","timestamp":1398017902000},"page":"7217-7222","source":"Crossref","is-referenced-by-count":39,"title":["Induction of Central Tolerance by Mature T Cells"],"prefix":"10.1093","volume":"173","author":[{"given":"Chaorui","family":"Tian","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessamyn","family":"Bagley","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daron","family":"Forman","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Iacomini","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,12,15]]},"reference":[{"key":"2026020212104007100_R1","first-page":"603","volume-title":"Nature","year":"1953"},{"key":"2026020212104007100_R2","first-page":"34","volume-title":"J. 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