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Upon adoptive transfer, the expression of CD25 in donor-derived cells is not stable, with CD4+CD25+ cells appearing in CD4+CD25\u2212 T cell-injected animals and vice versa. We show in this study that CD25+ cells arising from donor CD25\u2212 cells upon homeostatic proliferation in recipient mice express markers of freshly isolated Treg cells, display an anergic state, and suppress the proliferation of other cells in vitro. The maintenance of CD25 expression by CD4+CD25+ cells depends on IL-2 secreted by cotransferred CD4+CD25\u2212 or by Ag-stimulated T cells in peripheral lymphoid organs.<\/jats:p>","DOI":"10.4049\/jimmunol.173.12.7259","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:18:22Z","timestamp":1398017902000},"page":"7259-7268","source":"Crossref","is-referenced-by-count":274,"title":["CD25\u2212 T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion"],"prefix":"10.1093","volume":"173","author":[{"given":"Maria A","family":"Curotto de Lafaille","sequence":"first","affiliation":[{"name":"Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia C","family":"Lino","sequence":"additional","affiliation":[{"name":"Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Kutchukhidze","sequence":"additional","affiliation":[{"name":"Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J","family":"Lafaille","sequence":"additional","affiliation":[{"name":"Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,12,15]]},"reference":[{"key":"2026020212080386600_R1","first-page":"649","volume-title":"Curr. 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