{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:48:03Z","timestamp":1790333283291,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Both the type I (IFN-\u03b1\u03b2) and type II (IFN-\u03b3) IFNs have been heavily implicated in the pathogenesis of systemic lupus erythematosus. To test the relative roles of these systems, congenic lupus-prone MRL\/CD95lpr\/lpr (MRL\/lpr) mice lacking the type I IFN receptor (IFN-RI), type II IFN receptor (IFN-RII), or both, were derived. As expected, deficiency for IFN-RII protected MRL\/lpr mice from the development of significant autoimmune-associated lymphadenopathy, autoantibodies, and renal disease. However, deficiency for the IFN-RI surprisingly worsened lymphoproliferation, autoantibody production, and end organ disease; animals doubly deficient for IFN-RI and IFN-RII developed an autoimmune phenotype intermediate between wild-type and IFN-RII-deficient animals, all correlating with an ability of type I IFN to suppress MRL B cell activation. Thus, type I IFNs protect against both the humoral and end organ autoimmune syndrome of MRL\/lpr mice, independent of IFN-\u03b3. These findings warrant caution in the use of type I IFN antagonists in the treatment of autoimmune diseases and suggest further investigation into the interplay between the types I and II IFNs during the ontogeny of pathogenic autoantibodies.<\/jats:p>","DOI":"10.4049\/jimmunol.173.3.2134","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T23:38:25Z","timestamp":1398209905000},"page":"2134-2142","source":"Crossref","is-referenced-by-count":168,"title":["Type I IFN Protects Against Murine Lupus"],"prefix":"10.1093","volume":"173","author":[{"given":"Jonathan D","family":"Hron","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanford L","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO"},{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,8,1]]},"reference":[{"key":"2026020212075152000_R1","first-page":"5","volume-title":"N. Engl. J. Med.","year":"1979"},{"key":"2026020212075152000_R2","first-page":"429","volume-title":"Science","year":"1982"},{"key":"2026020212075152000_R3","first-page":"401","volume-title":"Arthritis Rheum.","year":"1982"},{"key":"2026020212075152000_R4","first-page":"1540","volume-title":"Science","year":"2001"},{"key":"2026020212075152000_R5","first-page":"2610","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026020212075152000_R6","first-page":"711","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026020212075152000_R7","first-page":"1431","volume-title":"Arthritis Rheum.","year":"2000"},{"key":"2026020212075152000_R8","first-page":"944","volume-title":"Science","year":"1987"},{"key":"2026020212075152000_R9","first-page":"2121","volume-title":"J. Immunol.","year":"1988"},{"key":"2026020212075152000_R10","first-page":"1179","volume-title":"J. Exp. Med.","year":"1991"},{"key":"2026020212075152000_R11","first-page":"5545","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026020212075152000_R12","first-page":"461","volume-title":"Immunity","year":"2001"},{"key":"2026020212075152000_R13","first-page":"1936","volume-title":"J. Clin. Invest.","year":"1997"},{"key":"2026020212075152000_R14","first-page":"364","volume-title":"J. Clin. Invest.","year":"1998"},{"key":"2026020212075152000_R15","first-page":"5484","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020212075152000_R16","first-page":"494","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020212075152000_R17","first-page":"438","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2026020212075152000_R18","first-page":"207","volume-title":"J. Clin. Invest.","year":"2000"},{"key":"2026020212075152000_R19","first-page":"2173","volume-title":"Kidney Int.","year":"2001"},{"key":"2026020212075152000_R20","first-page":"777","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026020212075152000_R21","first-page":"15","volume-title":"J. Autoimmun.","year":"2003"},{"key":"2026020212075152000_R22","first-page":"1655","volume-title":"J. Exp. Med.","year":"1993"},{"key":"2026020212075152000_R23","first-page":"70","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2026020212075152000_R24","first-page":"749","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026020212075152000_R25","first-page":"661","volume-title":"Immunity","year":"2001"},{"key":"2026020212075152000_R26","first-page":"15137","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2026020212075152000_R27","first-page":"435","volume-title":"Immunity","year":"2001"},{"key":"2026020212075152000_R28","first-page":"1198","volume-title":"J. Exp. Med.","year":"1978"},{"key":"2026020212075152000_R29","first-page":"220","volume-title":"Clin. Immunol. Immunopathol.","year":"1985"},{"key":"2026020212075152000_R30","first-page":"4041","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020212075152000_R31","first-page":"1742","volume-title":"Science","year":"1993"},{"key":"2026020212075152000_R32","first-page":"1918","volume-title":"Science","year":"1994"},{"key":"2026020212075152000_R33","first-page":"1645","volume-title":"J. Exp. Med.","year":"1992"},{"key":"2026020212075152000_R34","first-page":"696","volume-title":"J. Clin. Invest.","year":"1998"},{"key":"2026020212075152000_R35","first-page":"6999","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020212075152000_R36","first-page":"2616","volume-title":"Arthritis Rheum.","year":"1999"},{"key":"2026020212075152000_R37","first-page":"362","volume-title":"BioTechniques","year":"1996"},{"key":"2026020212075152000_R38","first-page":"365","volume-title":"Immunity","year":"1994"},{"key":"2026020212075152000_R39","first-page":"5689","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020212075152000_R40","first-page":"937","volume-title":"Int. Immunol.","year":"2003"},{"key":"2026020212075152000_R41","first-page":"1017","volume-title":"Science","year":"2004"},{"key":"2026020212075152000_R42","first-page":"4792","volume-title":"J. Virol.","year":"1995"},{"key":"2026020212075152000_R43","first-page":"861","volume-title":"Immunology","year":"1977"},{"key":"2026020212075152000_R44","first-page":"411","volume-title":"Int. Immunol.","year":"2002"},{"key":"2026020212075152000_R45","first-page":"2354","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020212075152000_R46","first-page":"42","volume-title":"Ann. Intern. Med.","year":"1995"},{"key":"2026020212075152000_R47","first-page":"940","volume-title":"Ann. Intern. Med.","year":"1995"},{"key":"2026020212075152000_R48","first-page":"1069","volume-title":"J. Interferon Cytokine Res.","year":"1999"},{"key":"2026020212075152000_R49","first-page":"443","volume-title":"Cell","year":"1996"},{"key":"2026020212075152000_R50","first-page":"431","volume-title":"Cell","year":"1996"},{"key":"2026020212075152000_R51","first-page":"6680","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2026020212075152000_R52","first-page":"6674","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/3\/2134\/62610237\/2134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/3\/2134\/62610237\/2134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:08:39Z","timestamp":1770052119000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/173\/3\/2134\/8035273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,1]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,8,1]]},"published-print":{"date-parts":[[2004,8,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.173.3.2134","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,8]]},"published":{"date-parts":[[2004,8,1]]}}}