{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:14:57Z","timestamp":1791080097914,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A strong CD4+ T cell response has been correlated with better control of HIV infection. However, the effect of HIV on the maintenance of Ag-specific memory CD4+ T cells is not fully understood. We characterized the function and phenotype of memory CD4+ T cells generated by mumps and influenza A or B viruses in HIV-infected individuals receiving highly active antiretroviral therapy (n = 21), HIV-infected long-term nonprogressors (n = 10), and HIV-seronegative volunteers (n = 10). We observed significantly decreased proliferation of the Ag-specific central memory CD4+ T cell population (CD28+\/CCR7+\/CD45RA\u2212) in the antiretroviral treated HIV-infected individuals compared with the seronegative controls. Restored CD4+ T cell count and decreased HIV viral load while on highly active antiretroviral therapy did not result in increased proliferation, whereas nadir CD4+ T cell count predicted the presence of Ag-specific proliferation. Our results indicate that HIV infection leads to impaired maintenance of virus-induced or vaccine-generated central memory CD4+ T cells that is not restored by HAART.<\/jats:p>","DOI":"10.4049\/jimmunol.173.3.2184","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T23:38:25Z","timestamp":1398209905000},"page":"2184-2189","source":"Crossref","is-referenced-by-count":61,"title":["Central Memory CD4+ T Cell Responses in Chronic HIV Infection Are Not Restored by Antiretroviral Therapy"],"prefix":"10.1093","volume":"173","author":[{"given":"Mohamed","family":"Elrefaei","sequence":"first","affiliation":[{"name":"California Department of Health Services , Richmond, CA 94804"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"McElroy","sequence":"additional","affiliation":[{"name":"California Department of Health Services , Richmond, CA 94804"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P","family":"Preas","sequence":"additional","affiliation":[{"name":"California Department of Health Services , Richmond, CA 94804"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hoh","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California , San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Deeks","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California , San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huyen","family":"Cao","sequence":"additional","affiliation":[{"name":"California Department of Health Services , Richmond, CA 94804"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,8,1]]},"reference":[{"key":"2026020212062946500_R1","first-page":"835","volume-title":"Nat. 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