{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:13:21Z","timestamp":1790842401365,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Classical CD4+ and CD8+ T cells recognize Ag presented by MHC class II (MHCII) and MHC class I (MHCI), respectively. However, our results show that CD4\u2212\/\u2212 mice mount a strong, readily detectable CD8+ T cell response to MHCII-restricted epitopes after a primary bacterial or viral infection. These MHCII-restricted CD8+CD4\u2212 T cells are more similar to classical CD8+ T cells than to CD4+ T cells in their expression of effector functions during a primary infection, yet they also differ from MHCI-restricted CD8+ T cells by their inability to produce high levels of the cytolytic molecule granzyme B. After resolution of a primary infection, epitope-specific MHCII-restricted T cells in CD4\u2212\/\u2212 mice persist for a long period of time as memory T cells. Surprisingly, upon reinfection the secondary MHCII-restricted response in CD4\u2212\/\u2212 mice consists mainly of CD8\u2212CD4\u2212 T cells. In contrast to CD8+ T cells, MHCII-restricted CD8\u2212CD4\u2212 T cells are capable of producing IL-2 in addition to IFN-\u03b3 and thus appear to have attributes characteristic of CD4+ T cells rather than CD8+ T cells. Therefore, MHCII-restricted T cells in CD4\u2212\/\u2212 mice do not share all phenotypic and functional characteristics with MHCI-restricted CD8+ T cells or with MHCII-restricted CD4+ T cells, but, rather, adopt attributes from each of these subsets. These results have implications for understanding thymic T cell selection and for elucidating the mechanisms regulating the peripheral immune response and memory differentiation.<\/jats:p>","DOI":"10.4049\/jimmunol.173.4.2494","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T04:58:37Z","timestamp":1398142717000},"page":"2494-2499","source":"Crossref","is-referenced-by-count":44,"title":["Functional Characterization of MHC Class II-Restricted CD8+CD4\u2212 and CD8\u2212CD4\u2212 T Cell Responses to Infection in CD4\u2212\/\u2212 Mice"],"prefix":"10.1093","volume":"173","author":[{"given":"Erika L","family":"Pearce","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon J","family":"Shedlock","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,8,15]]},"reference":[{"key":"2025032617325741700_R1","first-page":"89","volume-title":"Curr. 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