{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:58:25Z","timestamp":1784804305261,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Elevated levels of serotonin (5-hydroxytryptamine, 5-HT) are observed in the serum of asthmatics. Herein, we demonstrate that 5-HT functions independently as an eosinophil chemoattractant that acts additively with eotaxin. 5-HT2A receptor antagonists (including MDL-100907 and cyproheptadine (CYP)) were found to inhibit 5-HT-induced, but not eotaxin-induced migration. Intravital microscopy studies revealed that eosinophils roll in response to 5-HT in venules under conditions of physiological shear stress, which could be blocked by pretreating eosinophils with CYP. OVA-induced pulmonary eosinophilia in wild-type mice was significantly inhibited using CYP alone and maximally in combination with a CCR3 receptor antagonist. Interestingly, OVA-induced pulmonary eosinophilia in eotaxin-knockout (Eot\u2212\/\u2212) mice was inhibited by treatment with the 5-HT2A but not CCR3 receptor antagonist. These results suggest that 5-HT is a potent eosinophil-active chemoattractant that can function additively with eotaxin and a dual CCR3\/5-HT2A receptor antagonist may be more effective in blocking allergen-induced eosinophil recruitment.<\/jats:p>","DOI":"10.4049\/jimmunol.173.6.3599","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T02:57:29Z","timestamp":1398049049000},"page":"3599-3603","source":"Crossref","is-referenced-by-count":93,"title":["Cutting Edge: Serotonin Is a Chemotactic Factor for Eosinophils and Functions Additively with Eotaxin"],"prefix":"10.1093","volume":"173","author":[{"given":"Stefen A","family":"Boehme","sequence":"first","affiliation":[{"name":"La Jolla Institute for Molecular Medicine , San Diego, CA 92121"},{"name":"Neurocrine Biosciences, Inc. , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco M","family":"Lio","sequence":"additional","affiliation":[{"name":"Neurocrine Biosciences, Inc. , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila","family":"Sikora","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Molecular Medicine , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terlika S","family":"Pandit","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Molecular Medicine , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Lavrador","sequence":"additional","affiliation":[{"name":"Neurocrine Biosciences, Inc. , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita P","family":"Rao","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Molecular Medicine , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sriramarao","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Molecular Medicine , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,9,15]]},"reference":[{"key":"2025032617335994200_R1","first-page":"109s","volume-title":"Eur. Respir. J. Suppl.","year":"1996"},{"key":"2025032617335994200_R2","first-page":"373","volume-title":"Am. Rev. Respir. Dis.","year":"1985"},{"key":"2025032617335994200_R3","first-page":"411","volume-title":"Clin. Allergy","year":"1985"},{"key":"2025032617335994200_R4","first-page":"1110","volume-title":"N. Engl. J. Med.","year":"1991"},{"key":"2025032617335994200_R5","first-page":"785","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2025032617335994200_R6","first-page":"1479","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2025032617335994200_R7","first-page":"2332","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2025032617335994200_R8","first-page":"226","volume-title":"J. Lab. Clin. Med.","year":"2001"},{"key":"2025032617335994200_R9","first-page":"13","volume-title":"Trends Pharmacol. Sci.","year":"2000"},{"key":"2025032617335994200_R10","first-page":"12","volume-title":"Int. Arch. Allergy Immunol.","year":"2002"},{"key":"2025032617335994200_R11","first-page":"1611","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032617335994200_R12","first-page":"4238","volume-title":"J. Immunol.","year":"1994"},{"key":"2025032617335994200_R13","first-page":"684","volume-title":"J. Pharmacol. Exp. Ther.","year":"1993"},{"key":"2025032617335994200_R14","first-page":"116","volume-title":"Neuropsychopharmacology","year":"1996"},{"key":"2025032617335994200_R15","first-page":"218","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"1998"},{"key":"2025032617335994200_R16","first-page":"1083","volume-title":"Neuropharmacology","year":"1999"},{"key":"2025032617335994200_R17","first-page":"720","volume-title":"J. Pharmacol. Exp. Ther.","year":"1996"},{"key":"2025032617335994200_R18","first-page":"1127","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032617335994200_R19","first-page":"565","volume-title":"Nature","year":"1998"},{"key":"2025032617335994200_R20","first-page":"857","volume-title":"Br. J. Pharmacol.","year":"1998"},{"key":"2025032617335994200_R21","first-page":"151","volume-title":"Allergy","year":"1990"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/6\/3599\/62607626\/3599.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/173\/6\/3599\/62607626\/3599.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T18:21:02Z","timestamp":1743272462000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/173\/6\/3599\/8035332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,9,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.173.6.3599","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,9]]},"published":{"date-parts":[[2004,9]]}}}