{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:46:31Z","timestamp":1791071191896,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The immunologic requirements for generating long-lived protective CD8 T cell memory remain unclear. Memory CD8 populations generated in the absence of CD4 Th cells reportedly have functional defects, and at least a subset of CD8 T cells transiently express CD40 after activation, suggesting that direct CD4-CD8 T cell interactions through CD40 may influence the magnitude and functional quality of memory CD8 populations. To ascertain the role of CD40 in such direct T cell interactions, we investigated CD8 T cell responses in CD40\u2212\/\u2212 mice after infection with Listeria monocytogenes, an intracellular bacterium that induces APC activation and thus priming of CD8 T cells independently of CD4 Th cell help through CD40. In this study we show that memory CD8 T cells generated in CD40-deficient mice show in vivo cytotoxicity and cytokine production equivalent to CD8 memory T cells from wild-type mice. Upon secondary Listeria infection, CD40\u2212\/\u2212 memory CD8 T cells expand to greater numbers than seen in wild-type mice. These results indicate that CD40 ligation on CD8 T cells, although reportedly a part of CD8 T cell memory development in an H-Y-directed response, is not needed for the development of functional memory CD8 T cell populations after Listeria infection.<\/jats:p>","DOI":"10.4049\/jimmunol.173.6.4084","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T02:57:29Z","timestamp":1398049049000},"page":"4084-4090","source":"Crossref","is-referenced-by-count":10,"title":["The Development of Functional CD8 T Cell Memory after <i>Listeria monocytogenes<\/i> Infection Is Not Dependent on CD40"],"prefix":"10.1093","volume":"173","author":[{"given":"Megan J","family":"Montfort","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Oregon Health and Science University , Portland, OR 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H G Archie","family":"Bouwer","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Oregon Health and Science University , Portland, OR 97239"},{"name":"Department of Earle A. Chiles Research Institute, Providence Portland Medical Center , Portland, OR 97213"},{"name":"Department of Immunology Research, Veterans Affairs Medical Center , Portland, OR 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia R","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oregon Health and Science University , Portland, OR 97239"},{"name":"Department of Immunology Research, Veterans Affairs Medical Center , Portland, OR 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Hinrichs","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Oregon Health and Science University , Portland, OR 97239"},{"name":"Department of Earle A. Chiles Research Institute, Providence Portland Medical Center , Portland, OR 97213"},{"name":"Department of Immunology Research, Veterans Affairs Medical Center , Portland, OR 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,9,15]]},"reference":[{"key":"2025032617334427600_R1","first-page":"245","volume-title":"Nature","year":"1998"},{"key":"2025032617334427600_R2","first-page":"474","volume-title":"Nature","year":"1998"},{"key":"2025032617334427600_R3","first-page":"480","volume-title":"Nature","year":"1998"},{"key":"2025032617334427600_R4","first-page":"478","volume-title":"Nature","year":"1998"},{"key":"2025032617334427600_R5","first-page":"2053","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032617334427600_R6","first-page":"3402","volume-title":"J. Immunol.","year":"2001"},{"key":"2025032617334427600_R7","first-page":"1275","volume-title":"J. Exp. 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