{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:06:11Z","timestamp":1791223571099,"version":"4.1.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The lack of a mouse model of acute rectocolitis mimicking human bacillary dysentery in the presence of invasive Shigella is a major handicap to study the pathogenesis of the disease and to develop a Shigella vaccine. The inability of the mouse intestinal mucosa to elicit an inflammatory infiltrate composed primarily of polymorphonuclear leukocytes (PMN) may be due to a defect in epithelial invasion, in the sensing of invading bacteria, or in the effector mechanisms that recruit the PMN infiltrate. We demonstrate that the BALB\/cJ mouse colonic epithelium not only can be invaded by Shigella, but also elicits an inflammatory infiltrate that, however, lacks PMN. This observation points to a major defect of mice in effector mechanisms, particularly the lack of expression of the CXC chemokine, IL-8. Indeed, this work demonstrates that the delivery of recombinant human IL-8, together with Shigella infection of the colonic epithelial surface, causes an acute colitis characterized by a strong PMN infiltrate that, by all criteria, including transcription profiles of key mediators of the innate\/inflammatory response and histopathological lesions, mimics bacillary dysentery. This is a major step forward in the development of a murine model of bacillary dysentery.<\/jats:p>","DOI":"10.4049\/jimmunol.173.6.4197","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T02:57:29Z","timestamp":1398049049000},"page":"4197-4206","source":"Crossref","is-referenced-by-count":163,"title":["IL-8 Is a Key Chemokine Regulating Neutrophil Recruitment in a New Mouse Model of <i>Shigella-<\/i>Induced Colitis"],"prefix":"10.1093","volume":"173","author":[{"given":"Monique","family":"Singer","sequence":"first","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe J","family":"Sansonetti","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,9,15]]},"reference":[{"key":"2025032617334900400_R1","first-page":"479","volume-title":"Topley and Wilson\u2019s Microbiology and Microbial Infections","year":"1988"},{"key":"2025032617334900400_R2","first-page":"439","volume-title":"Acta Morphol. Acad. Sci. Hung.","year":"1962"},{"key":"2025032617334900400_R3","first-page":"481","volume-title":"Cell. Microbiol.","year":"2003"},{"key":"2025032617334900400_R4","first-page":"195","volume-title":"Immunol. Rev.","year":"1999"},{"key":"2025032617334900400_R5","first-page":"827","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2025032617334900400_R6","first-page":"1929","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032617334900400_R7","first-page":"1471","volume-title":"Infect. Immun.","year":"1999"},{"key":"2025032617334900400_R8","first-page":"1072","volume-title":"Infect. Immun.","year":"2001"},{"key":"2025032617334900400_R9","first-page":"932","volume-title":"EMBO Rep.","year":"2003"},{"key":"2025032617334900400_R10","first-page":"1584","volume-title":"Science","year":"2003"},{"key":"2025032617334900400_R11","first-page":"702","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2025032617334900400_R12","first-page":"903","volume-title":"J. 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Microbiol.","year":"1993"},{"key":"2025032617334900400_R23","first-page":"351","volume-title":"Escherichia coli. Ann. Microbiol. (Paris)","year":"1982"},{"key":"2025032617334900400_R24","first-page":"2820","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1988"},{"key":"2025032617334900400_R25","first-page":"21","volume-title":"Biochem. Pharmacol.","year":"2002"},{"key":"2025032617334900400_R26","first-page":"29","volume-title":"Gastroenterology","year":"1989"},{"key":"2025032617334900400_R27","first-page":"487","volume-title":"Gut","year":"1997"},{"key":"2025032617334900400_R28","first-page":"74","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"2002"},{"key":"2025032617334900400_R29","first-page":"410","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"2003"},{"key":"2025032617334900400_R30","first-page":"175","volume-title":"J. Immunol. Methods","year":"1999"},{"key":"2025032617334900400_R31","first-page":"L808","volume-title":"Am. J. Physiol.","year":"2003"},{"key":"2025032617334900400_R32","first-page":"L260","volume-title":"Am. J. Physiol.","year":"2003"},{"key":"2025032617334900400_R33","first-page":"7002","volume-title":"Infect. Immun.","year":"2003"},{"key":"2025032617334900400_R34","first-page":"5338","volume-title":"Infect. Immun.","year":"1997"},{"key":"2025032617334900400_R35","first-page":"884","volume-title":"J. Clin. Invest.","year":"1995"},{"key":"2025032617334900400_R36","first-page":"581","volume-title":"Immunity","year":"2000"},{"key":"2025032617334900400_R37","first-page":"3012","volume-title":"Infect. Immun.","year":"1998"},{"key":"2025032617334900400_R38","first-page":"730","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2025032617334900400_R39","first-page":"S311","volume-title":"Rev. Infect. Dis.","year":"1991"},{"key":"2025032617334900400_R40","first-page":"197","volume-title":"Adv. Immunol.","year":"1994"},{"key":"2025032617334900400_R41","first-page":"31","volume-title":"Adv. Exp. 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Immunol.","year":"2002"},{"key":"2025032617334900400_R52","first-page":"316","volume-title":"Microbiol. Rev.","year":"1996"},{"key":"2025032617334900400_R53","first-page":"2401","volume-title":"Infect. Immun.","year":"1998"},{"key":"2025032617334900400_R54","first-page":"6435","volume-title":"Infect. Immun.","year":"2003"},{"key":"2025032617334900400_R55","first-page":"1307","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2025032617334900400_R56","first-page":"32895","volume-title":"J. Biol. Chem.","year":"1998"},{"key":"2025032617334900400_R57","first-page":"5488","volume-title":"Infect. Immun.","year":"2003"},{"key":"2025032617334900400_R58","first-page":"633","volume-title":"J. Clin. Invest.","year":"1994"},{"key":"2025032617334900400_R59","first-page":"6164","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032617334900400_R60","first-page":"3057","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2025032617334900400_R61","first-page":"769","volume-title":"J. Exp. 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