{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:37:05Z","timestamp":1789594625290,"version":"build-2803163510"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The pathology of ankylosing spondylitis, reactive arthritis, and other spondyloarthropathies (SpA) is closely associated with the human leukocyte class I Ag HLA-B27. A characteristic finding in SpA is inflammation of cartilage structures of the joint, in particular at the site of ligament\/tendon and bone junction (enthesitis). In this study, we investigated the role of CD8+ T cells in response to the cartilage proteoglycan aggrecan as a potential candidate autoantigen in BALB\/c-B27 transgenic mice. We identified four new HLA-B27-restricted nonamer peptides, one of them (no. 67) with a particularly strong T cell immunogenicity. Peptide no. 67 immunization was capable of stimulating HLA-B27-restricted, CD8+ T cells in BALB\/c-B27 transgenic animals, but not in wild-type BALB\/c mice. The peptide was specifically recognized on P815-B27 transfectants by HLA-B27-restricted CTLs, which were also detectable by HLA tetramer staining ex vivo as well as in situ. Most importantly, analysis of the joints from peptide no. 67-immunized mice induced typical histological signs of SpA. Our data indicate that HLA-B27-restricted epitopes derived from human aggrecan are involved in the induction of inflammation (tenosynovitis), underlining the importance of HLA-B27 in the pathogenesis of SpA.<\/jats:p>","DOI":"10.4049\/jimmunol.173.8.4859","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:29:16Z","timestamp":1398032956000},"page":"4859-4866","source":"Crossref","is-referenced-by-count":37,"title":["Identification of Novel Human Aggrecan T Cell Epitopes in HLA-B27 Transgenic Mice Associated with Spondyloarthropathy"],"prefix":"10.1093","volume":"173","author":[{"given":"Wolfgang","family":"Kuon","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Kuhne","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H","family":"Busch","sequence":"additional","affiliation":[{"name":"Institute for Microbiology, Immunology and Hygiene, Technische Universita\u0308t Mu\u0308nchen , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamir","family":"Atagunduz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Seipel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Morawietz","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Fernahl","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Appel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth H","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institute for Anthropology and Human Genetics, Ludwig-Maximilians-Universita\u0308t , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Krenn","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Sieper","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,10,15]]},"reference":[{"key":"2026020214111272600_R1","first-page":"137","volume-title":"Immunol. 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