{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:26:32Z","timestamp":1792700792240,"version":"4.5.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mast cells (MCs) are the primary effector cells in allergic reactions and have also been found to activate T cells and to reside in close physical proximity to T cells. However, the molecular mechanisms involved in the MC-T cell interaction remain unclear. We hypothesized that human tonsillar MCs, which locate in the interfollicular areas, might interact with T cells. Thus, we first established a culture system of human tonsillar MCs and then compared gene expression profiles of tonsillar MCs with that of lung MCs before and after aggregation of Fc\u03b5RI by using high-density oligonucleotide probe arrays. Here we show that resting tonsillar MCs, when compared with lung MCs, revealed significantly higher expression levels for CC chemokines (CCL3 and 4), which recruit T cells, and for TNFR superfamilies (OX40 ligand and 4-1BB ligand), which induce proliferation of T cells. After aggregation of Fc\u03b5RI, not only tonsillar MCs but also lung MCs up-regulated the expression of these molecules. We confirmed that T cell proliferation is induced in direct cross-talk by the MC surface molecule OX40 ligand. These results suggest that human MCs may play important roles in adaptive immunity through the T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.173.8.5247","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:29:16Z","timestamp":1398032956000},"page":"5247-5257","source":"Crossref","is-referenced-by-count":137,"title":["T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells"],"prefix":"10.1093","volume":"173","author":[{"given":"Jun-ichi","family":"Kashiwakura","sequence":"first","affiliation":[{"name":"Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research (RIKEN) Yokohama Institute , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Saito","sequence":"additional","affiliation":[{"name":"Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research (RIKEN) Yokohama Institute , Yokohama ,","place":["Japan"]},{"name":"Department of Allergy and Immunology, National Research Institute for Child Health and Development , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimichi","family":"Okayama","sequence":"additional","affiliation":[{"name":"Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research (RIKEN) Yokohama Institute , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,10,15]]},"reference":[{"key":"2026020214104610400_R1","first-page":"624","volume-title":"Curr. 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Immunol.","year":"2003"},{"key":"2026020214104610400_R22","first-page":"3338","volume-title":"Blood","year":"1998"},{"key":"2026020214104610400_R23","first-page":"405","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020214104610400_R24","first-page":"375","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020214104610400_R25","first-page":"315","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026020214104610400_R26","first-page":"875","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026020214104610400_R27","first-page":"401","volume-title":"Clin. Exp. Allergy","year":"1992"},{"key":"2026020214104610400_R28","first-page":"216","volume-title":"Int. Arch. Allergy Immunol.","year":"1992"},{"key":"2026020214104610400_R29","first-page":"246","volume-title":"Allergy","year":"1994"},{"key":"2026020214104610400_R30","first-page":"2547","volume-title":"Blood","year":"2003"},{"key":"2026020214104610400_R31","first-page":"1016","volume-title":"Blood","year":"2001"},{"key":"2026020214104610400_R32","first-page":"986","volume-title":"Genome Res.","year":"1996"},{"key":"2026020214104610400_R33","first-page":"E29","volume-title":"Nucleic Acids Res.","year":"2001"},{"key":"2026020214104610400_R34","first-page":"1127","volume-title":"Blood","year":"2001"},{"key":"2026020214104610400_R35","first-page":"3861","volume-title":"Blood","year":"2002"},{"key":"2026020214104610400_R36","first-page":"9","volume-title":"BMC Cell Biol.","year":"2002"},{"key":"2026020214104610400_R37","first-page":"1782","volume-title":"Clin. Exp. 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Immunol.","year":"2002"},{"key":"2026020214104610400_R47","first-page":"116","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020214104610400_R48","first-page":"41","volume-title":"Immunity","year":"1996"},{"key":"2026020214104610400_R49","first-page":"4026","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020214104610400_R50","first-page":"337","volume-title":"J. Leukocyte Biol.","year":"1998"},{"key":"2026020214104610400_R51","first-page":"55","volume-title":"J. Immunol. Methods","year":"1983"},{"key":"2026020214104610400_R52","first-page":"4827","volume-title":"Cancer Res.","year":"1988"},{"key":"2026020214104610400_R53","first-page":"257","volume-title":"J. Immunol. Methods","year":"1991"},{"key":"2026020214104610400_R54","first-page":"1695","volume-title":"Am. J. Pathol.","year":"2001"},{"key":"2026020214104610400_R55","first-page":"1509","volume-title":"J. Histochem. 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